Recruiting

Cannabis

Sponsor:

University of Colorado, Boulder

Code:

NCT06588582

Conditions

Cannabis Use

Stress

Eligibility Criteria

Sex: All

Age: 21 - 65

Healthy Volunteers: Accepted

Interventions

Water Temperature Variation - WW

Water Temperature Variation - CW

Study Details

Brief summary:

The purpose of the study is to better understand the effects of cannabis in relation to mental and physical states including its relationship with mood, cognition, perception including the experience of temperature and pain, and heart rate.

We expect that participants will be in this research study for approximately one week. The total amount of time that participants will spend completing study tasks will be about 2.5 hours across two separate in-person visits.

Conditions

Cannabis Use

Stress

Study ID

NCT06588582

Start date

Feb 17, 2025

Status verified date

Jun, 2025

Completion date

Jul 31, 2029

Anticipated

Primary completion date

Jul 1, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 65

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 21-65 years of age
  • Endorsement of at least some use of cannabis for coping purposes (>1 on CMMQ)
  • Regularly use flower cannabis products (i.e., ≥1x/week in the last 6 months)
  • Proficient in English language
  • At least occasional use of CBD+THC or CBD-dominant products (e.g., ≥1x/month)

Exclusion Criteria:

  • Diagnosis or use of medications for substance use or psychotic disorders
  • Report of other drug use (cocaine, opiates, methamphetamine) in the past 90 days or fail urine screen for any of these drugs
  • Females cannot be pregnant or trying to become pregnant or nursing mothers
  • Not able to provide informed consent

Study Design

Enrollment

166 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Cold Water

placebo comparator: Warm Water

Interventions

Water Temperature Variation - WW

Participants are assigned to warm water temperature.

Water Temperature Variation - CW

Participants are assigned to cold water temperature and are video recorded.

Primary outcome measure

  • Blood Cortisol Levels [ Time Frame: Pre-Use/Pre-Water Task, 20 minutes Post-Use, 40 minutes Post-Use ]
  • Cannabis Used [ Time Frame: Immediate Post-Use ]
  • Blood Endocannabinoid Levels [ Time Frame: Pre-Use/Pre-Water Task, 20 minutes Post-Use ]
  • Heart Rate [ Time Frame: Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use ]
  • Social Anxiety [ Time Frame: Pre-Use/Pre-Water Task ]
  • Inhibitory Control [ Time Frame: Baseline ]
  • Stress [ Time Frame: Pre-Use/Pre-Water Task ]
  • Blood cannabinoid levels [ Time Frame: Pre-Use/Pre-Water Task, 20 minutes Post-Use ]
  • Current Pain [ Time Frame: Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use ]
  • Mood [ Time Frame: Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use ]

Central Contacts and Locations

Central contacts

Carillon Skrzynski, PhD

(734)788-2961carillon.skrzynski@colorado.edu

Locations

University of Colorado at Boulder

Recruiting

Boulder, Colorado, United States, 80309

Contacts

Carillon Skrzynski, PhD

(734)788-2961carillon.skrzynski@colorado.edu

More Information

Sponsor

University of Colorado, Boulder

Last update posted

Jun 13, 2025

Last verified

Jun, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Colorado, Boulder on 2025-06-13.