Recruiting

Ketone Supplementation

Sponsor:

University of British Columbia

Code:

NCT06590623

Conditions

Ketosis, Metabolic

Immune Functions

Histone Deacetylase (HDAC) Activity

Eligibility Criteria

Sex: All

Age: 19+

Healthy Volunteers: Accepted

Interventions

Ketone Monoester (KE)

Study Details

Brief summary:

To conduct a single-arm pilot study to determine how acute ingestion of an exogenous ketone monoester supplement alters the histone lysine β-hydroxybutyrylation and immune function in healthy human monocytes and lymphocytes.

Conditions

Ketosis, Metabolic

Immune Functions

Histone Deacetylase (HDAC) Activity

Study ID

NCT06590623

Start date

Oct 1, 2024

Status verified date

Mar, 2025

Completion date

Jun 1, 2025

Anticipated

Primary completion date

Jun 1, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Over the age of 19
  • Able to fast overnight

Exclusion Criteria:

  • Being a competitive endurance athlete.
  • Following a ketogenic diet, low-calorie diet, periodic fasting regimen, or regularly consuming ketogenic supplements.
  • Being unable to travel to and from the university
  • Being pregnant.
  • Having been diagnosed with a chronic disorder of glucose or fat metabolism, including type 2 diabetes, chronic pancreatitis, or gallbladder disease
  • Being unable to read or communicate in English.

Study Design

Enrollment

12 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: exogenous ketone supplement

Participants will consume a ketone monoester supplement (KetoneAid KE4) at a dose of 0.75 g/kg of body weight.

Interventions

Ketone Monoester (KE)

Participants will receive an exogenous ketone supplement (KetoneAid KE4) in a fasted state in the morning, at a dosage of 0.75 g/kg of body weight.

Primary outcome measure

  • β-hydroxybutyrylation of histone in human immune cells using Western blotting [ Time Frame: Before (fasted state) and 2 hours after the consumption of the exogenous ketone supplement. ]

Central Contacts and Locations

Central contacts

Jonathan Little Principal Investigator, Professor Little, Ph.D

250-807-9876jonathan.little@ubc.ca

Locations

University of British Columbia Okanagan Campus

Recruiting

Kelowna, British Columbia, Canada, V1V1V7

Contacts

Alexis Marcotte-Chénard Postdoctoral fellow, Ph.D

250-807-9876alexis.marcottechenard@ubc.ca

More Information

Sponsor

University of British Columbia

Last update posted

Mar 7, 2025

Last verified

Mar, 2025

Keywords

  • Ketone supplement
  • Exogenous ketones
  • Immune function
  • β-hydroxybutyrylation
  • Beta-Hydroxybutyrate

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of British Columbia on 2025-03-07.