Recruiting

Genetic Initiative

Sponsor:

University of North Carolina, Chapel Hill

Code:

NCT06594913

Conditions

Anorexia Nervosa

Bulimia Nervosa

Binge-Eating Disorder

Avoidant Restrictive Food Intake Disorder

Eligibility Criteria

Sex: All

Age: 12 - 70+

Healthy Volunteers: Accepted

Interventions

Eating disorder diagnosis group

Study Details

Brief summary:

The overarching intention of the Eating Disorder Genetics Initiative 2 (EDGI2) is to increase sample size, diversity, and eating disorder phenotypes. The investigators are enrolling 20,000 new participants with anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), avoidant/restrictive food intake disorder (ARFID), and controls in the US, Mexico, Australia, New Zealand, Sweden, and Denmark. A primary study goal is to enroll at least 30% of participants from underrepresented groups. Participants are asked to complete a series of questionnaires and submit a saliva sample for genotyping. The goal is to better understand eating disorders and how they relate to each other so that better treatments can be developed.

Conditions

Anorexia Nervosa

Bulimia Nervosa

Binge-Eating Disorder

Avoidant Restrictive Food Intake Disorder

Study ID

NCT06594913

Start date

Oct 28, 2024

Status verified date

Jul, 2026

Completion date

Sep 1, 2027

Anticipated

Primary completion date

Sep 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 12 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • A lifetime history of anorexia nervosa, bulimia nervosa, binge-eating disorder, avoidant restrictive food intake disorders or no history of any disordered eating behavior, based on DSM-5 criteria algorithms
  • Age 12-99 years, depending on country. (US enrollment age is 18-99)

Exclusion Criteria:

  • History of subthreshold disordered eating behaviors.

Study Design

Enrollment

20000 participants

Anticipated

Interventions and Outcome Measures

Arms

Anorexia nervosa

Individuals with a self-reported lifetime history of anorexia nervosa.

Bulimia nervosa

Individuals with a self-reported lifetime history of bulimia nervosa.

Binge-eating disorder

Individuals with a self-reported lifetime history of binge-eating disorder.

ARFID

Individuals with a self-reported lifetime history of avoidant restrictive food intake disorder.

Control

Individuals with no history of disordered eating behaviors or symptoms

Interventions

Eating disorder diagnosis group

This is an observational study, no active intervention is applied. Participants are assigned to an eating disorder diagnosis group based on their lifetime history of disordered eating behaviors and symptoms.

Primary outcome measure

  • Number of Participants Identified with an Eating Disorder Diagnosis by Category [ Time Frame: Baseline ]
  • Age of eating disorder onset [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Laura M Thornton, PhD

804-690-3079laura_thornton@med.unc.edu

Casey MacDermod, BA

984-974-3798edgi2@unc.edu

Locations

University of North Carolina at Chapel Hill

Recruiting

Chapel Hill, North Carolina, United States, 27599-7160

Contacts

Laura M Thornton, PhD

804-690-3079laura_thornton@med.unc.edu

More Information

Sponsor

University of North Carolina, Chapel Hill

Last update posted

Jul 8, 2026

Last verified

Jul, 2026

Keywords

  • severe and enduring eating disorder
  • genetics
  • mental health
  • disordered eating
  • environmental factors

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of North Carolina, Chapel Hill on 2026-07-08.