Recruiting

CHEF Intervention

Sponsor:

Dana-Farber Cancer Institute

Code:

NCT06609473

Conditions

Childhood Cancer

Childhood Cancer Survivors

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Interventions

CHEF Intervention Program

Study Details

Brief summary:

The goal of the Cardiovascular Health Equity Through Food (CHEF) program is to make it easier for participants and families to cook and eat healthy foods during and following childhood cancer treatment with the long-term goal of supporting heart health.

Conditions

Childhood Cancer

Childhood Cancer Survivors

Study ID

NCT06609473

Start date

Apr 7, 2025

Status verified date

Apr, 2026

Completion date

Mar 30, 2028

Anticipated

Primary completion date

Sep 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Child with any primary cancer diagnosis (non-relapsed, non-secondary malignancy) who has received cancer-directed therapy that includes chemotherapy and/or radiation therapy;
  • Child is within one of the following time windows:

1. Among those receiving chemotherapy, any time from start of last planned cycle of chemotherapy until 12 months from completion of chemotherapy;
2. Among those receiving radiation therapy alone or radiation and surgery, any time from completion of radiation until 12 months post completion;
  • Child has 1 or more cardiovascular risk factor (defined as any of: body mass index ≥ 85th percentile; systolic or diastolic blood pressure ≥90th percentile; dyslipidemia \[triglycerides ≥150 mg/dL, total cholesterol ≥200 mg/dL, LDL cholesterol ≥130 mg/dL, HDL cholesterol ≤40 mg/dL\]; impaired glucose metabolism \[fasting glucose ≥100 mg/dL, hemoglobin A1c ≥5.7%\]; anthracycline exposure ≥100 mg/m2; or any radiation exposure to chest, brain, thoracic spine, or total body);
  • Child is ≤18 years of age at time of enrollment, or over 18 years of age but under medical guardianship;
  • Parent/guardian screened positive for food insecurity.\* \*Assessed through validated 2-item food insecurity screen.

Exclusion Criteria:

  • Patient received only surgery, or watchful waiting/surveillance, for cancer- directed therapy;
  • Foreign national family receiving cancer care as an embassy-pay patient.

Study Design

Enrollment

17 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: CHEF Program

Enrolled participants and caregivers will complete:

  • Baseline visit and survey
  • Meeting with a certified benefits counselor by phone or video teleconference
  • Kitchen equipment delivery
  • Weekly meal kit deliveries
  • Monthly grocery support via gift card
  • Second meeting with a certified benefits counselor
  • 3-month survey
  • Final survey and interview with study staff

Interventions

CHEF Intervention Program

Poverty-targeted intervention utilizing direct resource provision of healthy meal kits and groceries, as well as assisted referral and enrollment in government nutrition assistance benefits, SNAP (Supplement Nutrition Assistance Program) and/or WIC (Woman, Infants, and Children Program). Meal kits will be delivered by a commercial meal kit vendor. Grocery gift cards will be delivered via email, mail, or in-person. Kitchen equipment will be delivered to caregiver residence.

Primary outcome measure

  • Change in Dietary Quality Score [ Time Frame: From baseline to 6 months ]

Central Contacts and Locations

Central contacts

Rahela Aziz-Bose, MD

617-632-3352rahela_aziz-bose@dfci.harvard.edu

Locations

Boston Children's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Rahela Aziz-Bose, MD

617-632-3352Rahela_aziz-bose@dfci.harvard.edu

Principal Investigator:

Rahela Aziz-Bose, MD

Dana-Farber Cancer Institute

Recruiting

Boston, Massachusetts, United States, 02215

Contacts

Rahela Aziz-Bose, MD

617-632-3352Rahela_aziz-bose@dfci.harvard.edu

Principal Investigator:

Rahela Aziz-Bose, MD

More Information

Sponsor

Dana-Farber Cancer Institute

Last update posted

Apr 13, 2026

Last verified

Apr, 2026

Keywords

  • Cardiovascular Health
  • Childhood Cancer
  • Childhood Cancer Survivorship

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Dana-Farber Cancer Institute on 2026-04-13.