Recruiting

Observational Study

Sponsor:

Mayo Clinic

Code:

NCT06617195

Conditions

Aging

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Accepted

Interventions

Exercise

Study Details

Brief summary:

The purpose of this research is to understand how chronic inflammation affects muscle function and responses to exercise in older adults.

Conditions

Aging

Study ID

NCT06617195

Start date

Jan 14, 2025

Status verified date

Jan, 2026

Completion date

Sep 16, 2030

Anticipated

Primary completion date

Sep 16, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Accepted

Exclusion Criteria:

1. Diabetes or fasting plasma glucose 126 mg/dL
2. Body mass index (BMI) 30 kg/m2
3. Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl)
4. Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
5. Renal failure (serum creatinine \> 1.5mg/dl)
6. Chronic active liver disease (AST\>144IU/L or ALT\>165IU/L)
7. Oral warfarin group medications or history of blood clotting disorders.
8. Smoking
9. Pregnancy or breastfeeding
10. Alcohol consumption greater than 2 glasses/day or other substance abuse
11. Untreated or uncontrolled hypothyroidism
12. Debilitating chronic disease (at the discretion of the investigators)

Study Design

Enrollment

120 participants

Anticipated

Interventions and Outcome Measures

Arms

Young

Men and women between the ages of 21-35 years will be recruited for this study. All participants will complete an outpatient study day (body composition, blood draw, treadmill test, strength test) and an inpatient study day (muscle biopsies, fat biopsies, indirect calorimetry, exercise test).

Older

Men and women between the ages of 70-85 years will be recruited for this study. All participants will complete an outpatient study day (body composition, blood draw, treadmill test, strength test) and an inpatient study day (muscle biopsies, fat biopsies, indirect calorimetry, exercise test).

Interventions

Exercise

Young and older adults will perform a single bout of unaccustomed resistance exercise to evaluate molecular and cellular response in skeletal muscle

Primary outcome measure

  • Anabolic response [ Time Frame: 2 months ]

Central Contacts and Locations

Central contacts

Rachel Passehl

507-255-8112passehl.rachel@mayo.edu

Ian Lanza

lanza.ian@mayo.edu

Locations

Mayo Clinic

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Ian R Lanza, PhD

507-255-8147lanza.ian@mayo.edu

Principal Investigator:

Ian R Lanza, PhD

More Information

Sponsor

Mayo Clinic

Last update posted

Jan 21, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-01-21.