Recruiting

Observational Study

Sponsor:

Marquette University

Code:

NCT06624982

Conditions

Alveolar Bone Grafting

Bone Healing

Tooth Extraction Site Healing

Wound Healing

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

observational study

Study Details

Brief summary:

The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.

Conditions

Alveolar Bone Grafting

Bone Healing

Tooth Extraction Site Healing

Wound Healing

Study ID

NCT06624982

Start date

Oct 8, 2025

Status verified date

Nov, 2025

Completion date

Oct 1, 2027

Anticipated

Primary completion date

Oct 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adult patients (18-75 years)
  • Good general health (controlled conditions)
  • Controlled periodontal disease
  • Scheduled for single tooth extraction with bone graft placement and resorbable membrane
  • Tooth to be extracted must have adjacent teeth
  • Socket wall integrity

Exclusion Criteria:

  • Smoking
  • Pregnancy
  • Active periodontal disease
  • Systemic conditions that affect healing
  • Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and contraindications for tooth extraction.

Study Design

Enrollment

160 participants

Anticipated

Interventions and Outcome Measures

Arms

Non-molar sites with immediate post-extraction ridge expansion

Non-molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Non-molar sites with no immediate post-extraction ridge width change

Non-molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Molar sites with immediate post-extraction ridge expansion

Molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Molar sites with no immediate post-extraction ridge width change

Molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Interventions

observational study

Observational study; alveolar ridge preservation

Primary outcome measure

  • Buccolingual ridge width [ Time Frame: (1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation ]
  • Ridge height [ Time Frame: (1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation ]

Central Contacts and Locations

Central contacts

Vrisiis Kofina, DDS, MS

4142886521vrisiis.kofina@marquette.edu

Samah Rady, DDS

9497962173samahsy.rady@marquette.edu

Locations

Marquette University School of Dentistry Graduate Periodontics Clinic

Recruiting

Milwaukee, Wisconsin, United States, 53233

Contacts

Vrisiis Kofina, DDS, MS

4142886521vrisiis.kofina@marquette.edu

Arndt Guentsch, DMD, PhD, MHBA, MS

4142886089arndt.guentsch@marquette.edu

Principal Investigator:

Vrisiis Kofina, DDS, MS

More Information

Sponsor

Marquette University

Last update posted

Nov 17, 2025

Last verified

Nov, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Marquette University on 2025-11-17.