Recruiting

Observational Study

Sponsor:

Duke University

Code:

NCT06625684

Conditions

Glioblastoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The goal of this observational study is to find out what factors affect the health and risks in adults with glioblastoma (GBM), a grade 4 brain cancer.

The main questions it aims to answer are:

  • How do genetic and immune system factors impact survival and quality of life in GBM patients?
  • What occupational and medical history factors are linked to the risk of getting GBM?

Participants will:

  • Fill out an online survey about their medical history and lifestyle.

Participants will have the chance to give a blood sample (from the outer arm) for genetic and immune system testing. Blood samples will be given using a home collection kit provided by the study team.

Conditions

Glioblastoma

Study ID

NCT06625684

Start date

Dec 10, 2024

Status verified date

Jan, 2026

Completion date

Dec 10, 2029

Anticipated

Primary completion date

Dec 10, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • At least 18 years old
  • Pathologically-confirmed diagnosis of glioblastoma multiforme (GBM) or grade 4 brain tumor
  • Participant is accessible for follow-up (has a working email address)
  • Participant is willing and able to comply with the study requirements

Exclusion Criteria:

  • Those who cannot read either English or Spanish
  • Those who cannot view an online survey

Study Design

Enrollment

200 participants

Anticipated

Interventions and Outcome Measures

Arms

Adults with Glioblastoma

This group consists of adults diagnosed with glioblastoma, a type of aggressive brain tumor. Participants are observed to identify factors influencing their outcomes, including genetic, immunologic, and personal medical history factors. The study aims to explore how these factors impact survival rates and quality of life in this patient population. There are no specific interventions. Instead, the focus is on analyzing survey data and biological samples to understand risk factors and disease progression.

Primary outcome measure

  • Overall Survival [ Time Frame: From date of enrollment until date of death from any cause as submitted by caregiver, up to 60 months ]
  • Functional Well-being as measured by the Functional Assessment of Cancer Therapy-Brain (FACT-Br) questionnaire [ Time Frame: At time of study enrollment ]

Central Contacts and Locations

Central contacts

Quinn Ostrom, PhD

919 -684-5301GBMsurvey@duke.edu

Locations

Duke University

Recruiting

Durham, North Carolina, United States, 27710

Contacts

Quinn Ostrom, PhD

919-684-5301gbmsurvey@duke.edu

Principal Investigator:

Quinn Ostrom, PhD

More Information

Sponsor

Duke University

Last update posted

Jan 20, 2026

Last verified

Jan, 2026

Keywords

  • Glioblastoma
  • genetic predisposition to disease
  • risk factors
  • quality of life
  • questionnaires
  • blood sample
  • adult brain cancer
  • observational study
  • personal medical history
  • survival outcomes
  • cancer epidemiology
  • genetics, medical
  • immunologic factors
  • patient outcomes
  • health history
  • occupational exposure

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Duke University on 2026-01-20.