Recruiting

Observational Study

Sponsor:

University of Chicago

Code:

NCT06636318

Conditions

Sleep Deprivation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Blood Sample Collection

Actigraph (GT9X-BT) Monitor

Study Details

Brief summary:

Sleep deprivation is a prevalent problem in modern societies. Sleep deprivation can cause hormonal changes, such as an increase in cortisol, as well as inflammation. Animal studies have shown an increase in inflammatory cytokine production following sleep deprivation. Additionally, humans experiencing sleep deprivation may experience a decrease in natural killer cells and lymphocytes.

Physicians, particularly those in surgical specialties, are often subjected to sleep deprivation as part of their medical residency training. This study hypothesizes that after 24-hour shifts, there is an increase in inflammatory response and impairment of the immune response against unspecific activation. This proposal aims to provide insight into the impact of sleep deprivation on the immune system of surgery residents by characterizing the phenotype and function of immune cells, as well as their correlation with biometric data.

Conditions

Sleep Deprivation

Study ID

NCT06636318

Start date

Oct 17, 2024

Status verified date

Dec, 2025

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Healthy subjects
  • Surgery residents in a 24-hour shift rotation
  • Gender of subjects: Males and females
  • Age of subjects: 18 years old and older
  • Racial and Ethnic Origin: Any race or ethnicity

Exclusion Criteria:

  • Unwilling/unable to sign informed consent
  • Vulnerable Subjects/Subject Capacity to provide consent

Study Design

Enrollment

60 participants

Anticipated

Interventions and Outcome Measures

Arms

General Surgery Residents

General Surgery residents on during 24-hour rotation shifts

Interventions

Blood Sample Collection

To characterize the phenotype and function of immune cells in surgery residents before and after a 24-hour shift, and before and after a month of being "on call". Along with to investigate the relationship between sleep deprivation, physical activity, and different immune responses.

Actigraph (GT9X-BT) Monitor

Participants will be asked to wear their monitor every day for a week. The monitor will collect their step count, sleep and heart rate automatically. Participants will return their monitor at visit 5 (day 30) of the study.

Primary outcome measure

  • Characterization of the phenotype and function of immune cells using flow cytometry [ Time Frame: 24 hours ]

Central Contacts and Locations

Central contacts

Angelica Perez-Gutierrez, MD

773-834-5087rperezgutierrez@bsd.uchicago.edu

Leila Yazdanbakhsh

leila.yazdanbakhsh@bsd.uchicago.edu

Locations

The University of Chicago

Recruiting

Chicago, Illinois, United States, 60637

Contacts

Shalitha Johnson

773-834-8758sjohnson28@bsd.uchicago.edu

Leila Yazdanbakhsh

773-834-5087leila.yazdanbakhsh@bsd.uchicago.edu

Principal Investigator:

Angelica Perez-Gutierrez, MD

More Information

Sponsor

University of Chicago

Last update posted

Dec 9, 2025

Last verified

Dec, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Chicago on 2025-12-09.