Recruiting

UPDOs & PrEP

Sponsor:

Duke University

Code:

NCT06638892

Conditions

HIV Prevention

PrEP

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Accepted

Interventions

Using PrEP, Doing it for Ourselves (UPDOs)

Standard of Care

Study Details

Brief summary:

The goal of this clinical trial is to test a new online program called UPDOs Protective Styles to help people in the southeastern United States learn about and start using PrEP (pre-exposure prophylaxis), a medicine that helps prevent HIV. The study focuses on people who may be at higher risk for HIV and have not had equal access to PrEP.

The main questions it aims to answer are:

Does UPDOs help more people trust and understand PrEP? Does UPDOs increase the number of people who start and continue using PrEP?

Researchers will compare two groups:

One group will use UPDOs, which includes six weekly videos, blog discussions, and access to telehealth services through Q Care Plus. The other group will receive standard HIV prevention materials from the CDC.

Participants will:

Be recruited from 32 beauty salons in areas with high HIV rates. Complete surveys at the start of the study and again at 6, 12, 24, 32, and 52 weeks.

Have access to HIV testing and PrEP prescriptions through Q Care Plus.

This study will also look at how well the program works in different communities and how easy it is to use and share.

Conditions

HIV Prevention

PrEP

Study ID

NCT06638892

Start date

Feb 13, 2026

Status verified date

Feb, 2026

Completion date

Jan, 2030

Anticipated

Primary completion date

Jun, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Black
  • cisgender female
  • Ages 18+

Exclusion Criteria:

  • Under 18 years of age
  • Does not identify as Black
  • Not a cisgender female

Study Design

Enrollment

1000 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Using PrEP, Doing it for Ourselves (UPDOs) intervention

This group will receive the UPDOs intervention that includes "edutainment", e.g., videos, blogs, vlogs, and Q Care Plus.

other: Standard of Care

This group will receive CDC standard of care, e.g., CDC videos and website.

Interventions

Using PrEP, Doing it for Ourselves (UPDOs)

An e-Health intervention that considers women's lived experiences and uses three components: beauty salons and stylists as opinion leaders (trusted gatekeepers who share health information in the community), theory driven edutainment videos and blogs, and a secure online platform for accessing pre-exposure prophylaxis (PrEP).

Standard of Care

CDC standard of care, e.g., CDC videos and website.

Primary outcome measure

  • Pre-exposure prophylaxis (PrEP) Contemplation Ladder total score [ Time Frame: 12 weeks post-intervention ]

Central Contacts and Locations

Central contacts

Niasha Fray, MA, MSPH

919-668-8325Niasha.Fray@Duke.edu

Schenita Randolph, PhD

919-684-3786schenita.randolph@duke.edu

Locations

Duke University School of Nursing

Recruiting

Durham, North Carolina, United States, 27710

Contacts

Niasha Fray, MA, MSPH

9196688325niasha.fray@duke.edu

Principal Investigator:

Schenita Randolph, PhD, MPH, RN, FAAN

More Information

Sponsor

Duke University

Last update posted

Aug 28, 2026

Last verified

Feb, 2026

Keywords

  • Black Women
  • Community-based Research

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Duke University on 2026-08-28.