Observational StudyCHAAMP (CHArlotte Advocate MGUS Project) Internal Pilot Study

SCREENING Inclusion Criteria:

• Age 30 years or older at the time of consent
• Either:

1. Self-identify as Black and/or African American OR
2. First-degree relatives (parents, siblings, or children) of patients of any race or ethnicity diagnosed with a plasma cell disorder, including MGUS, smoldering multiple myeloma (SMM), multiple myeloma (MM), solitary plasmacytoma, plasma cell leukemia, AL amyloidosis, POEMS syndrome, and Waldenström's Macroglobulinemia

• Capable and willing to provide informed consent. NOTE: HIPAA (Health Insurance Portability and Accountability Act) authorization for the release of personal health information may be included in the informed consent or obtained separately
• Reside in Charlotte, NC, or the surrounding area, based on self-report

SCREENING Exclusion Criteria:

• Self-reported history of MGUS, SMM, MM, AL amyloidosis, plasma cell leukemia, solitary plasmacytoma, Waldenstrom Macroglobulinemia, and POEMS.

LONGITUDINAL Inclusion Criteria:

• Test positive for monoclonal gammopathy during screening portion of the study
• Consent to the longitudinal portion of the study

LONGITUDINAL Exclusion Criteria:

• The participant previously underwent diagnostic work up as part of CHAAMP Internal Pilot that did not result in a diagnosis of MGUS, Smoldering Multiple Myeloma or other non-plasma cell disorder.