Recruiting

Nerve Transfer Techniques

Sponsor:

M.D. Anderson Cancer Center

Code:

NCT06667427

Conditions

Cancer

Head and Neck Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Nerve transfer techniques

Study Details

Brief summary:

The goal of this research study is to measure changes in patients' quality of life after surgeries that affect the facial nerve, including nerve transfer as treatment for facial paralysis.

Conditions

Cancer

Head and Neck Cancer

Study ID

NCT06667427

Start date

Jan 13, 2025

Status verified date

Mar, 2026

Completion date

Aug 1, 2028

Anticipated

Primary completion date

Aug 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

In order to be eligible to participate in the intervention group of this study, an individual must meet all of the following criteria:

  • Provision of signed and dated informed consent form
  • Aged 18 or greater
  • Patient scheduled to undergo facial nerve transfer
  • Stated willingness to comply with all study procedures and lifestyle considerations and availability for the duration of the study

In order to be eligible to participate in the non-intervention historical control group of this study, an individual must meet all of the following criteria:

  • Provision of signed and dated informed consent form
  • Aged 18 or greater
  • Previous facial surgery severing a facial nerve without graft or other form of dynamic facial nerve reconstruction within the last 20 years

Exclusion Criteria:

Patients known to be pregnant

Study Design

Enrollment

40 participants

Anticipated

Allocation

Non randomized

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Control

Participants will be identified and recruited during their visit to the Center of Reconstructive Surgery.

experimental: Surgery

Interventions

Nerve transfer techniques

Participants will undergo facial nerve reconstruction using nerve transfer techniques

Primary outcome measure

  • Safety and Adverse Events (AEs) [ Time Frame: Through study completion; an average of 1 year ]

Central Contacts and Locations

Central contacts

Z-Hye Lee, MD

713-563-4598zlee@mdanderson.org

Locations

The University of Texas M. D. Anderson Cancer Center

Recruiting

Houston, Texas, United States, 77030

Contacts

Z-Hye Lee, MD

713-563-4598zlee@mdanderson.org

Principal Investigator:

Z-Hye Lee, MD

More Information

Sponsor

M.D. Anderson Cancer Center

Last update posted

Mar 11, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by M.D. Anderson Cancer Center on 2026-03-11.