Recruiting

PE+

Sponsor:

University of Vermont

Code:

NCT06670079

Conditions

Posttraumatic Stress Disorder

Pregnancy

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Prolonged exposure therapy + incentives for therapy session attendance

Study Details

Brief summary:

The goal of this clinical trial is to learn if a treatment for adults with PTSD called prolonged exposure + incentives (PE+) works to treat pregnant patients. The main question it aims to answer is:

Does PE+ decrease PTSD symptoms?

All participants will receive PE+ to see if their PTSD symptoms at the end of the trial are less than at the beginning.

Participants will:

  • Receive individual PE+ therapy for 1 hour weekly for 12 weeks.
  • Receive financial incentives for attending each PE+ session.
  • Attend assessment visits every 4 weeks for the 12 weeks of the trial.
  • Allow research staff to collect some information about their labor and delivery from their medical records after their babies are born.

Conditions

Posttraumatic Stress Disorder

Pregnancy

Study ID

NCT06670079

Start date

Feb 5, 2026

Status verified date

May, 2026

Completion date

Jul 22, 2027

Anticipated

Primary completion date

Jul 15, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Female
  • >18 years old
  • Gestational age ≤ 25 weeks
  • Meet current DSM-5 posttraumatic stress disorder criteria based on the Clinician Administered PTSD Scale for DSM-5
  • Participants receiving psychotropic medications must be maintained on a stable dose for >14 days prior to enrollment.

Exclusion Criteria:

  • Male
  • Under 18 years old
  • Gestational age > 25 weeks
  • No current diagnosis of PTSD
  • Current delusions or hallucinations, unstable bipolar disorder, imminent risk for suicide as assessed by the Mini International Neuropsychiatric Interview
  • Enrolled in another ongoing evidence-based treatment for PTSD.

Study Design

Enrollment

30 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Prolonged exposure therapy + incentives for therapy session attendance

Interventions

Prolonged exposure therapy + incentives for therapy session attendance

Prolonged exposure therapy plus incentives for therapy session attendance

Primary outcome measure

  • Change in Posttraumatic Stress Disorder Symptom Severity - Clinician Rated [ Time Frame: From baseline to the 12-week assessment ]
  • Acceptability of prolonged exposure therapy + incentives for therapy session attendance [ Time Frame: From baseline to the 12-week assessment ]

Central Contacts and Locations

Central contacts

Kelly Peck, PhD

802-656-9610kelly.peck@uvm.edu

Locations

University of Vermont

Recruiting

Burlington, Vermont, United States, 05401

Contacts

Kelly Peck

8026569610kelly.peck@uvm.edu

More Information

Sponsor

University of Vermont

Last update posted

May 13, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Vermont on 2026-05-13.