Recruiting
Phase 1

Meditative Neurofeedback

Sponsor:

UCLA

Code:

NCT06675240

Conditions

Depression - Major Depressive Disorder

Depression Disorders

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MediNF

ShamMediNF

Study Details

Brief summary:

The goal of this study is to test a meditative neurofeedback intervention for depressed mood.

Conditions

Depression - Major Depressive Disorder

Depression Disorders

Study ID

NCT06675240

Start date

Nov 15, 2024

Status verified date

Oct, 2026

Completion date

Nov 15, 2027

Anticipated

Primary completion date

Nov 15, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • moderate depression per PHQ9 symptom ratings

Exclusion Criteria:

  • active substance abuse/dependence
  • psychotic disorders
  • bipolar disorder
  • displaying acutely suicidal behaviors

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: MediNF

Over 5-sessions participants will engage in a breath-focused meditative practice with frontal brain connectivity neurofeedback provided to enhance performance.

sham comparator: ShamMediNF

Over 5-sessions participants will engage in a breath-focused meditative practice with frontal brain connectivity neurofeedback provided that is yoked to a closely-matched individual in the experimental arm.

no intervention: No Contact

No contact during the 4 week intervention period

Interventions

MediNF

Over 5-sessions participants will engage in a breath-focused meditative practice with frontal brain connectivity neurofeedback provided to enhance performance.

ShamMediNF

Over 5-sessions participants will engage in a breath-focused meditative practice with frontal brain connectivity neurofeedback provided that is yoked to a closely-matched individual in the experimental arm.

Primary outcome measure

  • Change in FCz-FC4 alpha band coherence (iCoh) [ Time Frame: 8 weeks ]

Central Contacts and Locations

Central contacts

Jyoti Mishra, PhD

858-621-1517braine@ucsd.edu

Locations

University of California San Diego

Recruiting

La Jolla, California, United States, 92093

Contacts

Jyoti Mishra

858-621-1517braine@ucsd.edu

More Information

Sponsor

University of California, San Diego

Last update posted

Oct 9, 2026

Last verified

Oct, 2026

Keywords

  • meditation
  • neurofeedback
  • rumination
  • EEG
  • anxiety
  • depression

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-23. This information was provided to ClinicalTrials.gov by University of California, San Diego on 2026-10-09. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.