Recruiting

Sentinel

Sponsor:

Massachusetts General Hospital

Code:

NCT06676852

Conditions

Hematopoietic Cell Transplant

Hematologic Malignancy

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Primary palliative care

Study Details

Brief summary:

Primary PC - or training HCT clinicians to deliver PC domains as part of routine practice - is an alternative model of supportive care. We have developed Sentinel, a primary PC intervention for HCT clinicians and patients. This study will assess Sentinel's feasibility and acceptability.

Conditions

Hematopoietic Cell Transplant

Hematologic Malignancy

Study ID

NCT06676852

Start date

Jan 5, 2026

Status verified date

Apr, 2026

Completion date

Mar 30, 2027

Anticipated

Primary completion date

Dec 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 years or older
  • Undergoing autologous or allogeneic HCT at MGH

Exclusion Criteria:

  • Prior receipt of inpatient specialty palliative care on two prior admissions in the past 6 months.
  • Significant uncontrolled psychiatric disorders (psychotic disorder, bipolar disorder, major depression) or other co-morbid disease (dementia, cognitive impairment), which the primary oncologist believes prohibits informed consent or ability to participate in study procedures
  • Inability to comprehend English as this is a preliminary/pilot study

Study Design

Enrollment

40 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Sentinel, primary palliative care intervention

All participants will receive Sentinel, a primary palliative care intervention, in this single-arm feasibility trial. Participants will complete patient-reported assessments at the following time points:

  • Baseline (prior to HCT admission)
  • Week-2 of HCT hospitalization (+/- 3 business days)
  • 1 month post-HCT (+/- 7 business days)
  • 3 months post-HCT (+/- 7 business days)

Interventions

Primary palliative care

Enrolled patient participants will receive Sentinel prior to and during their hospitalization for HCT. Prior to HCT, a transplant clinician (nurse practitioner - NP) will conduct a focused PC visit to build rapport, manage expectations regarding HCT, review anticipated symptoms, and discuss illness coping strategies. During the HCT hospitalization, HCT physicians and advanced practice providers will incorporate PC domains into their routine care of patients undergoing HCT.

Primary outcome measure

  • Feasibility [ Time Frame: Up to Day 90 ]

Central Contacts and Locations

Central contacts

Richard A Newcomb, MD

617-996-7584richard.newcomb@mgh.harvard.edu

Locations

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02152

Contacts

Richard A Newcomb, MD

617-996-7584richard.newcomb@mgh.harvard.edu

Principal Investigator:

Richard A Newcomb, MD

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Apr 24, 2026

Last verified

Apr, 2026

Keywords

  • palliative care
  • supportive care
  • primary palliative care
  • hematopoietic cell transplantation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2026-04-24.