Recruiting

Observational Study

Sponsor:

University of Guelph

Code:

NCT06679543

Conditions

Sleep Deprivation

Eligibility Criteria

Sex: All

Age: 18 - 50

Healthy Volunteers: Accepted

Interventions

Partial sleep deprivation

Study Details

Brief summary:

The goal of this clinical trial is to determine if attenuations in cardiac output drive the blunted blood pressure response during cycling exercise following a night of partial sleep deprivation in young healthy adults (%50 females). The secondary outcome is to assess sex differences. The main questions it aims to answer are:

  • Do reductions in plasma volume drive reductions in cardiac output and therefore blood pressure during exercise following a night of partial sleep deprivation?
  • Do sex differences exist?

Participants will:

  • Visit the lab after a night of normal sleep and a night of partial sleep deprivation.
  • Keep a daily diary of their sleep and food/beverage intake.
  • Perform maximal and submaximal exercise on a cycle ergometer.

Conditions

Sleep Deprivation

Study ID

NCT06679543

Start date

Jan 2, 2025

Status verified date

Apr, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 50

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Free of known cardiovascular or metabolic diseases or sleep disorders
  • No history of smoking (within the past 3 months)
  • Able to engage in physical activity assessed through the physical activity readiness questionnaire (PAR-Q+)
  • No prescription of chronic medications other than oral contraceptives
  • Able to abide by sleep protocols for all visits
  • Individuals who are not allergic to ultrasound gel
  • Individuals who are not pregnant

Exclusion Criteria:

  • Individuals diagnosed with cardiovascular or metabolic disease or sleep disorders
  • Has a history of smoking (within the past 3 months)
  • Not ready to engage in physical activity as assessed by the PAR-Q+
  • Individuals prescribed chronic medications other than oral contraceptives
  • Unable to abide by sleep protocols for any testing visit
  • Allergic to ultrasound gel
  • Pregnancy

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Other

Interventions and Outcome Measures

Arms

no intervention: Normal sleep

During this arm, participants will be asked to come to the lab for testing after a night of normal sleep. Normal sleep will be defined as participants habitual sleep-wake timing.

experimental: Partial sleep deprivation

During this arm, participants will be asked to come to the lab for testing after a night of partial sleep deprivation. Participants will be asked to fall asleep at their habitual bedtime but wake up early (\~40% of normal sleep duration).

Interventions

Partial sleep deprivation

Participants will be asked to come to the lab for testing after a night of partial sleep deprivation. Participants will be asked to fall asleep at their habitual bedtime but wake up early (\~40% of normal sleep duration).

Primary outcome measure

  • cardiac output responses to cycling exercise [ Time Frame: Comparison between normal sleep and partial sleep deprivation, ~3 weeks ]

Central Contacts and Locations

Central contacts

Julian Bommarito, MSc

9052209829jbomma01@uoguelph.ca

Locations

University of Guelph

Recruiting

Guelph, Ontario, Canada, N1G 2W1

Contacts

Julian Bommarito, MSc

9052209829jbomma01@uoguelph.ca

More Information

Sponsor

University of Guelph

Last update posted

Apr 28, 2026

Last verified

Apr, 2026

Keywords

  • exercise blood pressure
  • cardiac output
  • plasma volume
  • sleep deprivation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Guelph on 2026-04-28.