Recruiting

Heme Oxygenase

Sponsor:

Englewood Hospital and Medical Center

Code:

NCT06681818

Conditions

Liver Cancer Adult

Liver Regeneration

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

carbon monoxide measurement via smokerlyzer

Study Details

Brief summary:

the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.

Conditions

Liver Cancer Adult

Liver Regeneration

Study ID

NCT06681818

Start date

Nov 21, 2025

Status verified date

Nov, 2024

Completion date

Jan 1, 2039

Anticipated

Primary completion date

Jan 1, 2039

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patient plans to have partial liver resection for primary liver pathology or metastatic disease
  • Patient is able to comprehend and willing to sign the written consent form

Exclusion Criteria:

  • Patients < 18 years
  • Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test

Study Design

Enrollment

125 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: all participants

all participants will provide breath samples to detect carbon monoxide levels

Interventions

carbon monoxide measurement via smokerlyzer

participants in this study will provide breath samples for carbon monoxide measurements pre and post liver resection

Primary outcome measure

  • correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration [ Time Frame: measurements will be taken pre, then 4 hours and 24 hours post resection ]

Central Contacts and Locations

Central contacts

Jamie Ketas

2018943418jamie.ketas@ehmchealth.org

Raquel Molina

raquel.molina@ehmchealth.org

Locations

Englewood Hospital

Recruiting

Englewood, New Jersey, United States, 07631

Contacts

Jamie Ketas

2018943418jamie.ketas@ehmchealth.org

Raquel Molina

raquel.molina@ehmchealth.org

More Information

Sponsor

Englewood Hospital and Medical Center

Last update posted

Jul 23, 2025

Last verified

Nov, 2024

Keywords

  • hepatectomy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Englewood Hospital and Medical Center on 2025-07-23.