Recruiting

Observational Study

Sponsor:

Hospices Civils de Lyon

Code:

NCT06681844

Conditions

Prediction of Tooth Wear

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Tooth Shape assessed using an intraoral scanner one after avulsion

Study Details

Brief summary:

Tooth wear, resulting from gradual loss of dental hard tissue due to mechanical and chemical factors, impacts tooth structure, texture, and function. It affects quality of life, with varying prevalence (26.9% to 90.0%), and is traditionally detected visually during check-ups, often at advanced stages. Monitoring alterations in tooth shape via intraoral scanners aids early detection, but restoration remains challenging. Prevention through early detection is vital, as patients may not fully comprehend tooth structure loss until visible. Recently, statistical shape analysis (SSA) used to learn the tooth anatomy and define a reference shape (biogeneric tooth) using. However, assuring landmark consistency is challenging mostly due to biases of the operator. Recently, a robust method called MEG-IsoQuad offered automated, isotopological remeshing. Combining this with SSA holds promise for diagnostic and simulation purposes. This study aims to assess the reliability of a remeshing-SSA approach for altered and intact premolar analysis and compare machine learning algorithms for simulating the shape of the initially intact tooth or future altered one.

The clinical perspective of the current work offers possibilities to:

  • Prevent future tooth wear by detecting it at an early stage; and communicate better to the patient by presenting him/her potential future altered teeth
  • Simulate the adapted reconstruction for the altered tooth by simulating the initially intact one

Conditions

Prediction of Tooth Wear

Study ID

NCT06681844

Start date

Dec 12, 2023

Status verified date

Nov, 2024

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec 12, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • teeth avulsed presenting a tooth wear index between 0 and 3
  • mature incisor, canine, premolar or molars (1st and 2nd only)

Exclusion Criteria:

  • teeth avulsed presenting a tooth wear index over 3 (or presenting an oral rehabilitation representative of a similar wear)
  • immature teeth or teeth without root edification
  • wisdom teeth

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

all mature teeth presenting a tooth wear intact or presenting a tooth wear altered

Scaling of the tooth before scanning by the operator Evaluation of the tooh wear index 0 or 1 (by 2 calibrated experts )

Interventions

Tooth Shape assessed using an intraoral scanner one after avulsion

  • Tooth Shape assessed using an intraoral scanner one after avulsion and stored as StereoLithography (STL) file
  • Age, gender, reason of avulsion, type of tooth taken from the database and stored in a google sheet

Primary outcome measure

  • Prediction of the tooth wear index based on a dataset of dental shapes:a retrospective study [ Time Frame: only once ]

Central Contacts and Locations

Central contacts

Raphael Richet, Clinical Assistant

+33669523314raphael.richert@univ-lyon1.fr

Maxime Ducret, Professor

maxime.ducret@univ-lyon1.fr

Locations

Indiana University Hospital

Recruiting

Indianapolis, Indiana, United States, 46202

More Information

Sponsor

Hospices Civils de Lyon

Last update posted

Nov 8, 2024

Last verified

Nov, 2024

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Hospices Civils de Lyon on 2024-11-08.