Recruiting

Metabolic Outcomes

Sponsor:

University of Guelph

Code:

NCT06687122

Conditions

Obesity and Obesity-related Medical Conditions

Eligibility Criteria

Sex: All

Age: 30 - 65

Healthy Volunteers: Accepted

Interventions

3 whole eggs

Study Details

Brief summary:

The purpose of this research is to determine the effect of additional daily egg intake on metabolic phenotypes and metabolism in the context of obesity.

Conditions

Obesity and Obesity-related Medical Conditions

Study ID

NCT06687122

Start date

Jan 24, 2025

Status verified date

May, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 30 - 65

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Male or female participant of any race or ethnicity between 30-65 (inclusive) years of age
  • BMI > 30 kg/m2
  • Non-smoker
  • Willing to consume 3 eggs per day for one dietary period of 4 weeks
  • Willing to avoid eggs during the rest of the study except for eggs that are provided
  • Willing to follow the study protocol including maintaining usual lifestyle during the entire study

Exclusion Criteria:

  • Age < 30 or > 65 years
  • BMI < 30 kg/m2
  • Vegans or individuals who do not consume eggs
  • Individuals who are currently pregnant or planning to become pregnant during the course of the study; or are currently breastfeeding
  • Smokers, users of recreational drugs
  • Individuals taking antibiotics or natural health products including prebiotics or probiotics

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: 4 weeks of additional daily intake of 3 whole eggs

No intervention: 4 weeks of habitual diet without daily intake of eggs (baseline) will be followed by 4 weeks of additional daily intake of 3 whole eggs then no intervention: 4 weeks of habitual diet without daily intake of eggs (washout)

Interventions

3 whole eggs

Participants will be free-living and will not be supplied with any other food except for the eggs during the intervention period with no restrictions of energy intake.

Primary outcome measure

  • Liver physical density by imaging technologies [ Time Frame: Weeks 0, 4, 8 and 12 ]
  • Liver morphology as assessed by imaging technologies [ Time Frame: Weeks 0, 4, 8 and 12 ]
  • Concentration of circulating liver enzymes [ Time Frame: Weeks 0, 4, 8 and 12 ]
  • Concentration of circulating lipid markers [ Time Frame: Weeks 0, 4, 8 and 12 ]
  • Concentration of circulating glucose markers [ Time Frame: Weeks 0, 4, 8 and 12 ]
  • Body mass index in kg/m^2 [ Time Frame: Weeks 0, 4, 8 and 12 ]
  • Body circumference in metrics [ Time Frame: Weeks 0, 4, 8 and 12 ]

Central Contacts and Locations

Central contacts

Clara E. Cho, PhD

(519) 824-4120claracho@uoguelph.ca

Locations

Research Center of the Institut universitaire de cardiologie et de pneumologie de Québec - ULaval

Recruiting

Québec, Quebec, Canada, G1V 4G5

Contacts

Éric Paradis, PhD

(418) 656-8711eric.paradis@criucpq.ulaval.ca

More Information

Sponsor

University of Guelph

Last update posted

May 12, 2026

Last verified

May, 2026

Keywords

  • Eggs
  • Liver health
  • Obesity
  • Metabolism
  • Gut microbiome

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Guelph on 2026-05-12.