Recruiting

Photon-Counting CT

Sponsor:

University of Pennsylvania

Code:

NCT06691659

Conditions

Radiation Protection

Image Enhancement

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

CT-DACE

Study Details

Brief summary:

This project aims to develop and evaluate a next-generation photon-counting CT prototype, and assess whether next-generation photon-counting CT--which enables reduced radiation dose, high spatial resolution, and spectral imaging--would facilitate improved diagnostic performance for abdominal, cardiothoracic, musculoskeletal, and neuroimaging.

Conditions

Radiation Protection

Image Enhancement

Study ID

NCT06691659

Start date

Nov 19, 2024

Status verified date

Oct, 2025

Completion date

Nov 30, 2026

Anticipated

Primary completion date

Nov 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 to 89.
  • Participants must be informed of the investigational nature of this study and be willing to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures.
  • Not pregnant (based on attestation)

Exclusion Criteria:

  • Pregnant women will not be included. All females of childbearing potential must attest that they are not pregnant before CT imaging.
  • Participants with a known contrast allergy.
  • Any current medical condition, illness, or disorder, as assessed by medical record review and/or self-reported, that is considered by a physician investigator to be a condition that could compromise participant safety or successful participation in the study.

Study Design

Enrollment

250 participants

Anticipated

Interventions and Outcome Measures

Interventions

CT-DACE

Photon Counting CT scan

Primary outcome measure

  • Primary Outcome Measure [ Time Frame: 24 months ]

Central Contacts and Locations

Central contacts

Erin Schubert

215-573-6569erin.schubert@pennmedicine.upenn.edu

Hannah Straughn

443-739-4971hannah.straughn@pennmedicine.upenn.edu

Locations

University of Pennsylvania - Center for Advanced Computed Tomography Imaging Services (CACTIS)

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Erin Schubert

215-573-6569

Hannah Straughn

443-739-4971

Principal Investigator:

Peter Noel, PhD

More Information

Sponsor

University of Pennsylvania

Last update posted

Oct 14, 2025

Last verified

Oct, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by University of Pennsylvania on 2025-10-14.