Recruiting

ETT Suctioning

Sponsor:

Loma Linda University

Code:

NCT06692400

Conditions

Intensive Care Unit ICU

Intubation

Critical Illness

Mechanical Ventilation

Pain Measurement

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

endotracheal tube suctioning

Study Details

Brief summary:

The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be uncomfortable and cause stress.

The main questions this study aims to answer are:

Does ETT suctioning raise pain levels as measured by the Critical-Care Pain Observation Tool (CPOT)? Does ETT suctioning increase certain chemicals in the blood (hypoxanthine, xanthine, and uric acid) that show stress and lack of oxygen in the body? Researchers will compare patients who have ETT suctioning (intervention group) with those who do not have suctioning during the study period (control group) to see if there are differences in pain and blood markers of stress.

Participants will:

Have pain measured before and after suctioning using the CPOT. Have blood samples taken from an existing line at three time points: 5 minutes before, 5 minutes after, and 30 minutes after suctioning.

Provide demographic information (like age, gender, and diagnosis) from medical records.

This research will help improve how pain is managed for ICU patients who cannot speak for themselves, potentially leading to better pain relief methods in the future.

Conditions

Intensive Care Unit ICU

Intubation

Critical Illness

Mechanical Ventilation

Pain Measurement

Study ID

NCT06692400

Start date

Jan 30, 2025

Status verified date

Jul, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults (aged 18 years and older)
  • Current diagnosis of flu, pneumonia, COVID, or sepsis
  • Intubated and receiving mechanical ventilation.
  • Have arterial lines placed
  • Require endotracheal suctioning as part of their care

Exclusion Criteria:

  • Patients receiving neuromuscular blocking agents
  • Contraindications for blood draws (hemoglobin levels below 8.0 g/dL; Jehovah's Witness)

Study Design

Enrollment

110 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Participants who undergo endotracheal tube (ETT) suctioning.

Participants will receive ETT suctioning as part of routine care.

no intervention: Participants who do not undergo ETT suctioning during the observation period.

Participants will not receive ETT suctioning during the observation periood.

Interventions

endotracheal tube suctioning

Endotracheal tube suctioning occurs as part of normal care for intubated patients. This procedure will serve as the painful procedure to assess CPOT and biomarkers of hypoxia and oxidative stress.

Primary outcome measure

  • Impact of ETT suctioning on subject pain level [ Time Frame: Change between baseline CPOT score and 30-minutes post suctioning CPOT score. ]
  • Impact of ETT suctioning on subject serum markers of hypoxia and oxidative stress (Hypoxanthine). [ Time Frame: Change between baseline serum marker blood draw and 30-minutes post suctioning serum marker blood draw ]

Central Contacts and Locations

Central contacts

Briana Carr, PhD(c), BSN, RN

909-558-4000bmcarr@llu.edu

Locations

Loma Linda University Medical Center Troesh Medical Campus

Recruiting

Loma Linda, California, United States, 92354

Contacts

Loma Linda University Health

877-558-6248irb@llu.edu

Principal Investigator:

Briana Carr, PhD(c), MEd, BA, BSN, RN

More Information

Sponsor

Loma Linda University

Last update posted

Jul 10, 2026

Last verified

Jul, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Loma Linda University on 2026-07-10.