Recruiting

Local Anesthetics

Sponsor:

Weill Medical College of Cornell University

Code:

NCT06694714

Conditions

Anesthesia, Local

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

0.5 ml lidocaine + epinephrine 1:100,000

1.0 ml lidocaine + epinephrine 1:100,000

Study Details

Brief summary:

This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for. The investigators will investigate the role of anesthetic volume on the duration of action at highly vascular sites.

Conditions

Anesthesia, Local

Study ID

NCT06694714

Start date

Jan 21, 2025

Status verified date

Jan, 2026

Completion date

Jun 1, 2027

Anticipated

Primary completion date

Jun 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Male or female ≥ 18 years of age
  • Normal skin sensation at both nasal ala assessed by pinprick
  • Ability to provide informed consent

Exclusion Criteria:

  • Previous adverse reaction to local anesthetic or any components of the local anesthetics being evaluated
  • Pregnant or breastfeeding volunteers (assessed by self-report)
  • Patients taking monoamineoxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types

Study Design

Enrollment

35 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: 0.5 ml Lidocaine with epinephrine vs. 1.0 ml Lidocaine with epinephrine

Each side of the nasal ala will be tested for normal sensation using sterile 30-gauge needles. Other eligibility criteria will be confirmed. Participants in this arm will receive an injection of 0.5ml of Xylocaine + epinephrine 1:100,000 (lidocaine + epinephrine 1:100,000), buffered 1/10 with sodium bicarb into one side of the nose (nasal ala) and 1.0 ml of Xylocaine + epinephrine 1:100,000 (lidocaine + epinephrine 1:100,000), buffered 1/10 with sodium bicarb into the opposite nasal ala. Laterality of each anesthetic volume administration will be randomly assigned for each patient. Subjects will be evaluated for duration of effect of anesthesia every 15 minutes on both sides of the face, until the patient reports return of a sharp sensation upon the pinprick test.

experimental: 1.0 ml Lidocaine with epinephrine vs 0.5 ml Lidocaine with epinephrine

Each side of the nasal ala will be tested for normal sensation using sterile 30-gauge needles. Other eligibility criteria will be confirmed. Participants in this arm will receive an injection of 1.0ml of Xylocaine + epinephrine 1:100,000 (lidocaine + epinephrine 1:100,000), buffered 1/10 with sodium bicarb into one side of the nose (nasal ala) and 0.5 ml of Xylocaine + epinephrine 1:100,000 (lidocaine + epinephrine 1:100,000), buffered 1/10 with sodium bicarb into the opposite nasal ala. Laterality of each anesthetic volume administration will be randomly assigned for each patient. Subjects will be evaluated for duration of effect of anesthesia every 15 minutes on both sides of the face, until the patient reports return of a sharp sensation upon the pinprick test.

Interventions

0.5 ml lidocaine + epinephrine 1:100,000

0.5 ml lidocaine + epinephrine 1:100,000, buffered 1/10 with sodium bicarb

1.0 ml lidocaine + epinephrine 1:100,000

1.0 ml lidocaine + epinephrine 1:100,000, buffered 1/10 with sodium bicarb

Primary outcome measure

  • Time to Return to Baseline Sensation, as Determined by Binary Outcomes (Yes/no) in 15 Minute Increments [ Time Frame: Up to 4 hours. ]

Central Contacts and Locations

Central contacts

Benedict Ho, BA

646-962-6647beh2024@med.cornell.edu

Kira Minkis, MD PhD

646-962-6647kim9036@med.cornel.edu

Locations

Weill Cornell Medicine

Recruiting

New York, New York, United States, 10021

Contacts

Kira Minkis, MD, PhD

(646) 962-0033kim9036@med.cornell.edu

Benedict Ho, BA

9175025230beh2024@med.cornell.edu

Principal Investigator:

Kira Minkis, MD, PhD

More Information

Sponsor

Weill Medical College of Cornell University

Last update posted

Jan 22, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Weill Medical College of Cornell University on 2026-01-22.