Recruiting

Liquid Biopsies

Sponsor:

St. Joseph's Healthcare Hamilton

Code:

NCT06707519

Conditions

Lung Cancer

Circulating Tumor DNA

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The objective of the study is to determine the feasibility of recruiting participants and using sputum, Bronchoalveolar lavage (BAL) and exhaled Volatile Organic Compounds (VOC) in addition to blood, as biological samples for detecting mutations in extracted cell-free DNA in non-small cell lung cancer (NSCLC) patients, before and after surgery, and any recurrence within a 24-month postoperative follow-up period.

This is a pilot feasibility study, proposed as a 24-month prospective, single-center, non-interventional, observational trial with NSCLC-adenocarcinoma patients indicated for resection surgery with curative intent.

Conditions

Lung Cancer

Circulating Tumor DNA

Study ID

NCT06707519

Start date

Feb 1, 2023

Status verified date

Apr, 2026

Completion date

Dec 29, 2027

Anticipated

Primary completion date

Dec 29, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patient must be at least 18 years of age
  • Patient must be able to provide consent
  • Patients undergoing surgical resection with curative intent for non-small cell lung cancer at St. Joseph's Healthcare Hamilton and Firestone Institute for Respiratory Health.

Exclusion Criteria:

  • Resection done with non-curative intent or metastatic disease
  • other malignancies
  • Patients with previously treated malignancy less than 5 years prior to current resection (not including skin cancer).

Study Design

Enrollment

210 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Recruitment rate [ Time Frame: December 2025 ]
  • Data completion rate [ Time Frame: December 2025 ]
  • Safety, adverse events [ Time Frame: December 2025 ]

Central Contacts and Locations

Central contacts

Layla Halwagi, BSc

905-522-1155Lhalwagi@stjosham.on.ca

Locations

St. Joseph's Healthcare Hamilton

Recruiting

Hamilton, Ontario, Canada, L8N 4A6

Contacts

Layla Halwagi, BSc

905-522-1155Lhalwagi@stjosham.on.ca

Principal Investigator:

Yaron Shargall, MD

More Information

Sponsor

St. Joseph's Healthcare Hamilton

Last update posted

Apr 22, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by St. Joseph's Healthcare Hamilton on 2026-04-22.