Recruiting

TAMI

Sponsor:

UCLA

Code:

NCT06713603

Conditions

Smoking

Smoking Cessation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

TAMI Coach

Study Details

Brief summary:

Building on our successful pilot work to develop a Motivational Interviewing (MI)-capable chatbot and cessation coach, the investigators propose to address the problems of intrinsic motivation and social barriers to smoking cessation by evaluating a highly scalable and easily accessible digital-coaching intervention that 1) promotes readiness to change using a technology-assisted MI (TAMI) chatbot, 2) provides compelling and accessible multilingual education about smoking cessation tools, and 3) develops a tailored quit plan addressing social barriers to treatment initiation and sustainment.

Conditions

Smoking

Smoking Cessation

Study ID

NCT06713603

Start date

Sep 22, 2025

Status verified date

Oct, 2025

Completion date

May 31, 2027

Anticipated

Primary completion date

May 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • A current Primary Care Provider patient
  • Age 18 or older
  • Smoke at least 1 cigarette per day for the past 7 consecutive days (and at least 100 lifetime)
  • Have a digital device (phone, laptop, tablet)
  • Moderately proficient in English
  • Able to participate for 6-month trial

Exclusion Criteria:

  • Current participation in a smoking cessation program
  • Current use of Nicotine Replacement Therapy or smoking cessation pharmacotherapy
  • Cognitive impairment that would preclude informed consent

Study Design

Enrollment

440 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Technology Assisted Motivational Interviewing (TAMI)

Individuals randomized to TAMI will interact with the fully automated, web-based MI-chatbot for the 6-month study period. Patients who continue to smoke will receive up to two text messages per week with the chatbot URL link to initiate additional conversations always beginning with an assessment of readiness to change but "remembering" prior conversations much like a clinician. Individuals in the preparation stage will move directly to EBP education, tailoring a quit plan and boosting both self-efficacy and outcome expectancies. Patients with sufficient confidence will be encouraged to set a quit date. Patients will be encouraged to include their PCP and/or state quitline. TAMI will provide support proximal to the quit date including guidance through common obstacles. TAMI will check back to assess treatment initiation, treatment sustainment (and/or cessation), or relapse. Patients who are unable to quit (or who relapse) will be encouraged to restart conversations with TAMI.

no intervention: Usual Care

Individuals randomized to the Usual Care (UC) condition will receive a detailed educational handout on the health risks associated with smoking and information on Evidence Based Practice's (EBP) for cessation using the standard "Kick-It California" materials. Additional materials and referral resources regarding depression, stress, and other common barriers will be provided to all UC participants. Any UC individual can choose to quit at any time but they will not have access to TAMI. While this is not an "active" treatment condition, the handout and recurring assessments (at 3 and 6mo) may serve as reminders about the importance of quitting and may assist with finding support for co-occurring conditions or social needs.

Interventions

TAMI Coach

The investigators address the problems of intrinsic motivation, Evidence Based Practice (EBP) education, and referral tailoring using a digital-coaching intervention that 1) promotes readiness to change, 2) educates and builds confidence about EBP's, and 3) creates a tailored quit plan sensitive to social obstacles and needs.

Primary outcome measure

  • Biochemical verification of smoking abstinence [ Time Frame: 6-month ]

Central Contacts and Locations

Central contacts

Locations

San Francisco General Hospital

Recruiting

San Francisco, California, United States, 94110

Contacts

UCSF Adult Primary Care Mt. Zion Clinic

Recruiting

San Francisco, California, United States, 94115

Contacts

More Information

Sponsor

University of California, San Francisco

Last update posted

Oct 23, 2025

Last verified

Oct, 2025

Keywords

  • smoking
  • quit smoking
  • motivational interviewing
  • chatbot
  • cessation
  • coach
  • motivation
  • quit plan

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2025-10-23.