Recruiting

Metabolism Evaluation

Sponsor:

University of Kansas Medical Center

Code:

NCT06721260

Conditions

Bladder Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This study is being done to learn more about energy needs and muscle function during treatment for bladder cancer. These insights can help improve future patient care. The study team found in a previous study that resting energy can be different than what estimates show. Patients with bladder cancer are known to suffer a decline in physical resilience over time. Monitoring patients to understand these changes better could help design future treatments with these vulnerabilities in mind.

Conditions

Bladder Cancer

Study ID

NCT06721260

Start date

Jan 21, 2025

Status verified date

Mar, 2026

Completion date

Jun, 2027

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Confirmed cancer diagnosis
  • Scheduled for platinum-based chemotherapy followed by radical cystectomy
  • Adequate renal and cardiac function for platinum-based chemotherapy

Exclusion Criteria:

  • Prior chemotherapy or radiotherapy for bladder cancer
  • Severe cardiac, renal, hepatic, respiratory or metabolic diseases
  • Pregnant or breastfeeding
  • Uncontrolled conditions that could affect study outcomes

Study Design

Enrollment

30 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • To assess Resting Energy Expenditure (REE) changes across key treatment milestones. [ Time Frame: From enrollment, prior to chemotherapy, to 3 weeks after radical cystectomy. ]

Central Contacts and Locations

Central contacts

Jill M. Hamilton-Reeves, PhD, RD, CSO

913-588-7650jhamilton-reeves@kumc.edu

Misty D Bechtel, BA, CCRP

913-945-5037mbechtel2@kumc.edu

Locations

University of Kansas Medical Center

Recruiting

Kansas City, Kansas, United States, 66160

Contacts

Misty Bechtel

913-945-7519mbechtel@kumc.edu

Principal Investigator:

Jill Hamilton-Reeves, PhD

University of Kansas Medical Center

Recruiting

Kansas City, Kansas, United States, 66160

Principal Investigator:

Jill Hamilton-Reeves

More Information

Sponsor

University of Kansas Medical Center

Last update posted

Mar 20, 2026

Last verified

Mar, 2026

Keywords

  • Bladder cancer
  • resting energy expenditure
  • cachexia
  • growth differentiation factor 15 (GDF-15)
  • Nutrition status
  • radical cystectomy
  • neoadjuvant chemotherapy
  • body composition

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Kansas Medical Center on 2026-03-20.