Recruiting

Exercise & Nutrition

Sponsor:

UCLA

Code:

NCT06722508

Conditions

Head Cancer

Neck Cancer

Sarcopenia

Head and Neck Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

exercise and nutritional prehabilitation

Study Details

Brief summary:

This study examines the acceptability, feasibility, and safety in developing a prehabilitation program for head and neck cancer patients. The purpose of this research is to access the safety and acceptability of using a prehabilitation program before head and neck cancer surgery.

Conditions

Head Cancer

Neck Cancer

Sarcopenia

Head and Neck Cancer

Study ID

NCT06722508

Start date

May 9, 2024

Status verified date

Jan, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Aug, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

New head and neck cancer diagnosis Age > 18

Exclusion Criteria:

1. Prior treatment for head and neck cancer (surgery and/or radiation)
2. Acute or unstable cardiac conditions (unstable angina or symptomatic severe aortic stenosis)
3. American Society of Anesthesiologists physical status of 4 and 5
4. Disabling orthopedic or neuromuscular disease
5. Cardiac failure (New York Heart Association functional classes III and IV)
6. Severe chronic obstructive pulmonary disease
7. End-stage liver or kidney disease
8. Inability to swallow and/or feeding tube dependence
9. Any other comorbid medical, physical, and/or mental condition that contraindicates exercise or oral nutrition
10. Adults unable to consent
11. Age 17.99 or younger
12. Prisoners, pregnant women, or other vulnerable population

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: behavioral intervention

The study involves a behavioral intervention (exercise and nutritional prehabilitation) designed to assess outcomes related to feasibility, acceptability, and safety in head and neck cancer patients. Outcomes are being measured following the intervention over a defined period (from diagnosis through 1-month post-surgery).

Interventions

exercise and nutritional prehabilitation

The study involves a behavioral intervention (exercise and nutritional prehabilitation) designed to assess outcomes related to feasibility, acceptability, and safety in head and neck cancer patients. Outcomes are being measured following the intervention over a defined period (from diagnosis through 1-month post-surgery).

Primary outcome measure

  • Completion Rate of 2-Week Prehabilitation Program [ Time Frame: 2 weeks ]
  • Participant Safety During the 2-Week Program [ Time Frame: 2 weeks ]
  • Acceptability of the Program [ Time Frame: 2 weeks ]
  • Feasibility of the Program [ Time Frame: 2 weeks ]

Central Contacts and Locations

Central contacts

Randev Sandhu CRC Supervisor, BS

9167342863rssandhu@ucdavis.edu

Marianne Abouyared PI, MD

9167342801mabouyared@ucdavis.edu

Locations

UC Davis Health

Recruiting

Sacramento, California, United States, 95817

Contacts

Marianne Abouyared, MD

916-734-2704mabouyared@ucdavis.edu

UC Davis Medical Center

Recruiting

Sacramento, California, United States, 95817

Contacts

Randev Sandhu CRC Supervisor, BS

916-734-2863rssandhu@ucdavis.edu

Marianne Abouyared PI, MD

9167342801mabouyared@ucdavis.edu

Principal Investigator:

Marianne Abouyared PI, MD

More Information

Sponsor

University of California, Davis

Last update posted

Jan 15, 2026

Last verified

Jan, 2026

Keywords

  • Exercise
  • Nutritional
  • Prehabilitation
  • Head
  • Neck
  • Cancer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, Davis on 2026-01-15.