Recruiting
Phase 3

High Dose Chemotherapy & Autologous Stem Cells

Sponsor:

Eastern Cooperative Oncology Group

Code:

NCT06724237

Conditions

Anaplastic Large Cell Lymphoma, ALK-Negative

Follicular Helper T-Cell Lymphoma

Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type

Peripheral T-Cell Lymphoma, Not Otherwise Specified

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Autologous Hematopoietic Stem Cell Transplantation

Best Practice

Biospecimen Collection

Bone Marrow Aspiration

Bone Marrow Biopsy

Study Details

Brief summary:

This phase III trial compares the effect of high dose chemotherapy and the patients' own (autologous) stem cells to observation only in patients with peripheral T-cell lymphoma who achieved a complete response after initial chemotherapy. Usual treatment after a complete response may include observation or high dose chemotherapy followed by an autologous stem cell transplant, however, it is not known if a transplant if beneficial. Giving chemotherapy before a stem cell transplant helps kill cancer cells in the body and helps make room in the patient's bone marrow for new blood-forming cells (stem cells) to grow. Stem cells removed prior to treatment are then returned to the patient to replace the blood forming cells that were destroyed by the chemotherapy. Giving high dose chemotherapy followed by an autologous stem cell transplant may be more effective compared to observation only in treating patients with peripheral T-cell lymphoma who have achieved a complete response after initial chemotherapy.

Conditions

Anaplastic Large Cell Lymphoma, ALK-Negative

Follicular Helper T-Cell Lymphoma

Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type

Peripheral T-Cell Lymphoma, Not Otherwise Specified

Study ID

NCT06724237

Start date

Jan 30, 2025

Status verified date

Jul, 2026

Completion date

Dec 1, 2033

Anticipated

Primary completion date

Apr 30, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patient must be 18 to 75 years of age
  • Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-2
  • Patient must have histologically proven peripheral T-cell lymphoma (PTCL) in one of the following categories:

  • Anaplastic large cell lymphoma (ALCL) ALK-negative
  • Angioimmunoblastic T-cell lymphoma (AITL)
  • Nodal PTCL with follicular helper T cell (TFH) phenotype
  • Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS)
  • Patient must have undergone induction treatment with an anthracycline based chemotherapy.

  • NOTE: Patients who discontinued anthracycline during treatment are eligible as long as they received at least one dose and achieved complete remission
  • Patient must have achieved radiologic complete remission following induction therapy as defined by the Lugano criteria with a Deauville score between 1-3 by PET-CT

  • NOTE: There is no central review required. Confirmation of complete remission status is determined by the enrolling institution's review
  • NOTE: If a patient had a positive bone marrow biopsy at the time of initial diagnosis (pre-induction), a repeat biopsy must be completed post induction to confirm complete remission (CR)
  • Patient must be eligible for high dose chemotherapy and autologous stem cell transplant (ASCT) per the enrolling institutional guidelines at the transplant center and be ready to proceed with ASCT if randomized to the ASCT arm
  • Patient must not have active infection requiring intravenous systemic antimicrobial at time of randomization. Antibiotic prophylaxis is acceptable as long as the dose of the medication has been stable for at least 7 days prior to randomization
  • Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
  • Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All patients of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy. A patient of childbearing potential is defined as anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
  • Patient must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse during the treatment phase of the study and thereafter according to institutional guidelines
  • Absolute neutrophil count (ANC) ≥ 1000/mcL (obtained ≤ 14 days prior to protocol randomization)
  • Platelets ≥ 75,000/mcL (obtained ≤ 14 days prior to protocol randomization)
  • Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (obtained ≤ 14 days prior to protocol randomization)
  • Aspartate aminotransferase (AST)(serum glutamic oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT)(serum glutamic pyruvic transaminase \[SGPT\]) ≤ 3.0 x institutional ULN (obtained ≤ 14 days prior to protocol randomization)
  • Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial
  • For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
  • Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load

Study Design

Enrollment

294 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Arm I (observation)

Patients receive standard of care observation on study. Patients also undergo blood sample collection and optional bone marrow aspiration and biopsy on study, and CT or PET/CT throughout the study.

experimental: Arm II (high dose chemotherapy and ASCT)

Patients receive stem cell mobilization and then undergo leukapheresis per standard of care. Patients also receive high dose chemotherapy followed by ASCT per standard of care. Additionally, patients undergo blood sample collection and optional bone marrow aspiration and biopsy on study, and CT or PET/CT throughout the study.

Interventions

Autologous Hematopoietic Stem Cell Transplantation

Undergo ASCT

Best Practice

Receive standard of care observation

Biospecimen Collection

Undergo blood sample collection

Bone Marrow Aspiration

Undergo bone marrow aspiration and biopsy

Bone Marrow Biopsy

Undergo bone marrow aspiration and biopsy

Computed Tomography

Undergo CT or PET/CT

High Dose Chemotherapy

Receive high dose chemotherapy

Leukapheresis

Undergo leukapheresis

Positron Emission Tomography

Undergo PET/CT

Stem Cell Mobilization Therapy

Receive stem cell mobilization therapy

Primary outcome measure

  • Progression-free survival (PFS) [ Time Frame: From study randomization to documented disease progression or death, whichever occurs first, assessed up to 12 years ]

Central Contacts and Locations

Central contacts

Pamela Cogliano

857-504-2900ecog.rss@jimmy.harvard.edu

Locations

Anchorage Associates in Radiation Medicine

Recruiting

Anchorage, Alaska, United States, 98508

Contacts

Site Public Contact

907-212-6871AKPAMC.OncologyResearchSupport@providence.org

Principal Investigator:

Alison K. Conlin

Alaska Breast Care and Surgery LLC

Recruiting

Anchorage, Alaska, United States, 99508

Contacts

Site Public Contact

907-212-6871AKPAMC.OncologyResearchSupport@providence.org

Principal Investigator:

Alison K. Conlin

Alaska Oncology and Hematology LLC

Recruiting

Anchorage, Alaska, United States, 99508

Contacts

Site Public Contact

907-212-6871AKPAMC.OncologyResearchSupport@providence.org

Principal Investigator:

Alison K. Conlin

Alaska Women's Cancer Care

Recruiting

Anchorage, Alaska, United States, 99508

Contacts

Site Public Contact

907-212-6871AKPAMC.OncologyResearchSupport@providence.org

Principal Investigator:

Alison K. Conlin

Katmai Oncology Group

Recruiting

Anchorage, Alaska, United States, 99508

Contacts

Site Public Contact

907-212-6871AKPAMC.OncologyResearchSupport@providence.org

Principal Investigator:

Alison K. Conlin

Providence Alaska Medical Center

Recruiting

Anchorage, Alaska, United States, 99508

Contacts

Site Public Contact

907-212-6871AKPAMC.OncologyResearchSupport@providence.org

Principal Investigator:

Alison K. Conlin

Mayo Clinic Hospital in Arizona

Recruiting

Phoenix, Arizona, United States, 85054

Contacts

Site Public Contact

855-776-0015

Principal Investigator:

Nabila N. Bennani

Banner University Medical Center - Tucson

Recruiting

Tucson, Arizona, United States, 85719

Contacts

Site Public Contact

UACC-IIT@uacc.arizona.edu

Principal Investigator:

Muhammad Husnain

University of Arizona Cancer Center-North Campus

Recruiting

Tucson, Arizona, United States, 85719

Contacts

Site Public Contact

UACC-IIT@uacc.arizona.edu

Principal Investigator:

Muhammad Husnain

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Recruiting

Burbank, California, United States, 91505

Contacts

Site Public Contact

818-847-4793Najee.Boucher@providence.org

Principal Investigator:

Alison K. Conlin

City of Hope Comprehensive Cancer Center

Recruiting

Duarte, California, United States, 91010

Contacts

Site Public Contact

800-826-4673becomingapatient@coh.org

Principal Investigator:

Christina Poh

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Recruiting

Irvine, California, United States, 92612

Contacts

Site Public Contact

877-827-8839ucstudy@uci.edu

Principal Investigator:

Nicole Foley

Providence Queen of The Valley

Recruiting

Napa, California, United States, 94558

Contacts

Site Public Contact

707-521-3830

Principal Investigator:

Alison K. Conlin

UC Irvine Health/Chao Family Comprehensive Cancer Center

Recruiting

Orange, California, United States, 92868

Contacts

Site Public Contact

877-827-8839ucstudy@uci.edu

Principal Investigator:

Nicole Foley

Providence Medical Foundation - Santa Rosa

Recruiting

Santa Rosa, California, United States, 95403

Contacts

Site Public Contact

707-521-3830

Principal Investigator:

Alison K. Conlin

Providence Santa Rosa Memorial Hospital

Recruiting

Santa Rosa, California, United States, 95405

Contacts

Site Public Contact

707-521-3830

Principal Investigator:

Alison K. Conlin

Beebe Medical Center

Recruiting

Lewes, Delaware, United States, 19958

Contacts

Site Public Contact

302-291-6730research@beebehealthcare.org

Principal Investigator:

Gregory A. Masters

Beebe South Coastal Health Campus

Recruiting

Millville, Delaware, United States, 19967

Contacts

Site Public Contact

302-291-6730research@beebehealthcare.org

Principal Investigator:

Gregory A. Masters

Helen F Graham Cancer Center

Recruiting

Newark, Delaware, United States, 19713

Contacts

Site Public Contact

302-623-4450lbarone@christianacare.org

Principal Investigator:

Gregory A. Masters

Medical Oncology Hematology Consultants PA

Recruiting

Newark, Delaware, United States, 19713

Contacts

Site Public Contact

302-623-4450lbarone@christianacare.org

Principal Investigator:

Gregory A. Masters

Christiana Care Health System-Christiana Hospital

Recruiting

Newark, Delaware, United States, 19718

Contacts

Site Public Contact

302-623-4450lbarone@christianacare.org

Principal Investigator:

Gregory A. Masters

Beebe Health Campus

Recruiting

Rehoboth Beach, Delaware, United States, 19971

Contacts

Site Public Contact

302-291-6730research@beebehealthcare.org

Principal Investigator:

Gregory A. Masters

Christiana Care Health System-Wilmington Hospital

Recruiting

Wilmington, Delaware, United States, 19801

Contacts

Site Public Contact

302-623-4450lbarone@christianacare.org

Principal Investigator:

Gregory A. Masters

Sibley Memorial Hospital

Recruiting

Washington D.C., District of Columbia, United States, 20016

Contacts

Site Public Contact

202-243-2373jquiver1@jhmi.edu

Principal Investigator:

Cole H. Sterling

Mayo Clinic in Florida

Recruiting

Jacksonville, Florida, United States, 32224-9980

Contacts

Site Public Contact

855-776-0015

Principal Investigator:

Nabila N. Bennani

Moffitt Cancer Center-International Plaza

Recruiting

Tampa, Florida, United States, 33607

Contacts

Site Public Contact

800-679-0775ClinicalTrials@moffitt.org

Principal Investigator:

Aleksandr Lazaryan

Moffitt Cancer Center - McKinley Campus

Recruiting

Tampa, Florida, United States, 33612

Contacts

Site Public Contact

800-679-0775ClinicalTrials@moffitt.org

Principal Investigator:

Aleksandr Lazaryan

Moffitt Cancer Center

Recruiting

Tampa, Florida, United States, 33612

Contacts

Site Public Contact

800-679-0775ClinicalTrials@moffitt.org

Principal Investigator:

Aleksandr Lazaryan

Emory University Hospital/Winship Cancer Institute

Recruiting

Atlanta, Georgia, United States, 30322

Contacts

Site Public Contact

404-778-1868

Principal Investigator:

Pamela B. Allen

Saint Luke's Cancer Institute - Boise

Recruiting

Boise, Idaho, United States, 83712

Contacts

Site Public Contact

208-381-2774eslinget@slhs.org

Principal Investigator:

Alison K. Conlin

Saint Luke's Cancer Institute - Fruitland

Recruiting

Fruitland, Idaho, United States, 83619

Contacts

Site Public Contact

208-381-2774eslinget@slhs.org

Principal Investigator:

Alison K. Conlin

Saint Luke's Cancer Institute - Meridian

Recruiting

Meridian, Idaho, United States, 83642

Contacts

Site Public Contact

208-381-2774eslinget@slhs.org

Principal Investigator:

Alison K. Conlin

Saint Luke's Cancer Institute - Nampa

Recruiting

Nampa, Idaho, United States, 83687

Contacts

Site Public Contact

208-381-2774eslinget@slhs.org

Principal Investigator:

Alison K. Conlin

Saint Luke's Cancer Institute - Twin Falls

Recruiting

Twin Falls, Idaho, United States, 83301

Contacts

Site Public Contact

208-381-2774eslinget@slhs.org

Principal Investigator:

Alison K. Conlin

Loyola Center for Health at Burr Ridge

Recruiting

Burr Ridge, Illinois, United States, 60527

Contacts

Site Public Contact

708-216-9000

Principal Investigator:

Patrick A. Hagen

Loyola Medicine Homer Glen

Recruiting

Homer Glen, Illinois, United States, 60491

Contacts

Site Public Contact

708-216-9000

Principal Investigator:

Patrick A. Hagen

Loyola University Medical Center

Recruiting

Maywood, Illinois, United States, 60153

Contacts

Site Public Contact

708-226-4357

Principal Investigator:

Patrick A. Hagen

Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Recruiting

Melrose Park, Illinois, United States, 60160

Contacts

Site Public Contact

708-450-4554

Principal Investigator:

Patrick A. Hagen

Indiana University/Melvin and Bren Simon Cancer Center

Recruiting

Indianapolis, Indiana, United States, 46202

Contacts

Site Public Contact

317-278-5632iutrials@iu.edu

Principal Investigator:

Utpal P. Dave

University of Iowa/Holden Comprehensive Cancer Center

Recruiting

Iowa City, Iowa, United States, 52242

Contacts

Site Public Contact

800-237-1225

Principal Investigator:

Eric Mou

University of Kansas Cancer Center

Recruiting

Kansas City, Kansas, United States, 66160

Contacts

Site Public Contact

913-588-3671KUCC_Navigation@kumc.edu

Principal Investigator:

Marc S. Hoffmann

University of Kansas Cancer Center-Overland Park

Recruiting

Overland Park, Kansas, United States, 66210

Contacts

Site Public Contact

913-588-3671KUCC_Navigation@kumc.edu

Principal Investigator:

Marc S. Hoffmann

University of Kansas Hospital-Westwood Cancer Center

Recruiting

Westwood, Kansas, United States, 66205

Contacts

Site Public Contact

913-588-3671KUCC_Navigation@kumc.edu

Principal Investigator:

Marc S. Hoffmann

The James Graham Brown Cancer Center at University of Louisville

Recruiting

Louisville, Kentucky, United States, 40202

Contacts

Site Public Contact

502-562-3429

Principal Investigator:

Hassaan Yasin

UofL Health Medical Center Northeast

Recruiting

Louisville, Kentucky, United States, 40245

Contacts

Site Public Contact

502-852-2755ctoinfo@louisville.edu

Principal Investigator:

Hassaan Yasin

Ochsner Medical Center Jefferson

Recruiting

New Orleans, Louisiana, United States, 70121

Contacts

Site Public Contact

504-842-8084Elisemarie.curry@ochsner.org

Principal Investigator:

Ashley D. Staton

LSU Health Sciences Center at Shreveport

Recruiting

Shreveport, Louisiana, United States, 71103

Contacts

Site Public Contact

318-813-1404LPost@lsuhsc.edu

Principal Investigator:

Shashank Cingam

Johns Hopkins University/Sidney Kimmel Cancer Center

Recruiting

Baltimore, Maryland, United States, 21287

Contacts

Site Public Contact

410-955-8804jhcccro@jhmi.edu

Principal Investigator:

Cole H. Sterling

Christiana Care - Union Hospital

Recruiting

Elkton, Maryland, United States, 21921

Contacts

Site Public Contact

410-443-1360frank.crum@christianacare.org

Principal Investigator:

Gregory A. Masters

Wayne State University/Karmanos Cancer Institute

Recruiting

Detroit, Michigan, United States, 48201

Contacts

Site Public Contact

800-527-6266ctoadmin@karmanos.org

Principal Investigator:

Dipenkumar Modi

Weisberg Cancer Treatment Center

Recruiting

Farmington Hills, Michigan, United States, 48334

Contacts

Site Public Contact

313-576-9790ctoadmin@karmanos.org

Principal Investigator:

Dipenkumar Modi

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Site Public Contact

855-776-0015

Principal Investigator:

Nabila N. Bennani

Siteman Cancer Center at Saint Peters Hospital

Recruiting

City of Saint Peters, Missouri, United States, 63376

Contacts

Site Public Contact

800-600-3606info@siteman.wustl.edu

Principal Investigator:

Amanda F. Cashen

Siteman Cancer Center at West County Hospital

Recruiting

Creve Coeur, Missouri, United States, 63141

Contacts

Site Public Contact

800-600-3606info@siteman.wustl.edu

Principal Investigator:

Amanda F. Cashen

University of Kansas Cancer Center - Briarcliff

Recruiting

Kansas City, Missouri, United States, 64116

Contacts

Site Public Contact

913-588-3671

Principal Investigator:

Marc S. Hoffmann

University of Kansas Cancer Center - North

Recruiting

Kansas City, Missouri, United States, 64154

Contacts

Site Public Contact

913-588-3671KUCC_Navigation@kumc.edu

Principal Investigator:

Marc S. Hoffmann

University of Kansas Cancer Center - Lee's Summit

Recruiting

Lee's Summit, Missouri, United States, 64064

Contacts

Site Public Contact

913-588-3671KUCC_Navigation@kumc.edu

Principal Investigator:

Marc S. Hoffmann

Washington University School of Medicine

Recruiting

St Louis, Missouri, United States, 63110

Contacts

Site Public Contact

800-600-3606info@siteman.wustl.edu

Principal Investigator:

Amanda F. Cashen

Siteman Cancer Center-South County

Recruiting

St Louis, Missouri, United States, 63129

Contacts

Site Public Contact

800-600-3606info@siteman.wustl.edu

Principal Investigator:

Amanda F. Cashen

Siteman Cancer Center at Christian Hospital

Recruiting

St Louis, Missouri, United States, 63136

Contacts

Site Public Contact

800-600-3606info@siteman.wustl.edu

Principal Investigator:

Amanda F. Cashen

Saint Patrick Hospital - Community Hospital

Recruiting

Missoula, Montana, United States, 59802

Contacts

Site Public Contact

406-327-3118amy.hanneman@providence.org

Principal Investigator:

Alison K. Conlin

University of Rochester

Recruiting

Rochester, New York, United States, 14642

Contacts

Site Public Contact

585-275-5830

Principal Investigator:

Danielle Wallace

UNC Lineberger Comprehensive Cancer Center

Recruiting

Chapel Hill, North Carolina, United States, 27599

Contacts

Site Public Contact

877-668-0683cancerclinicaltrials@med.unc.edu

Principal Investigator:

Anne W. Beaven

Carolinas Medical Center/Levine Cancer Institute

Recruiting

Charlotte, North Carolina, United States, 28203

Contacts

Site Public Contact

800-804-9376

Principal Investigator:

Bei Hu

Novant Health Presbyterian Medical Center

Recruiting

Charlotte, North Carolina, United States, 28204

Contacts

Site Public Contact

980-201-6360kashah@novanthealth.org

Principal Investigator:

Alan P. Skarbnik

Wake Forest University at Clemmons

Recruiting

Clemmons, North Carolina, United States, 27012

Contacts

Site Public Contact

888-716-9259

Principal Investigator:

Rakhee Vaidya

Duke University Medical Center

Recruiting

Durham, North Carolina, United States, 27710

Contacts

Site Public Contact

888-275-3853

Principal Investigator:

Jie Wang

Novant Health Cancer Institute - Huntersville

Recruiting

Huntersville, North Carolina, United States, 28078

Contacts

Site Public Contact

980-201-6360kashah@novanthealth.org

Principal Investigator:

Alan P. Skarbnik

Novant Health Presbyterian Medical Center Huntersville

Recruiting

Huntersville, North Carolina, United States, 28078

Contacts

Site Public Contact

980-201-6360kashah@novanthealth.org

Principal Investigator:

Alan P. Skarbnik

Novant Health Cancer Institute - Kernersville

Recruiting

Kernersville, North Carolina, United States, 27284

Contacts

Site Public Contact

336-718-8335asmarrs@novanthealth.org

Principal Investigator:

James P. Dugan

Matthews Radiation Oncology Center

Recruiting

Matthews, North Carolina, United States, 28105

Contacts

Site Public Contact

980-201-6360kashah@novanthealth.org

Principal Investigator:

Alan P. Skarbnik

Novant Health Cancer Institute - Matthews

Recruiting

Matthews, North Carolina, United States, 28105

Contacts

Site Public Contact

980-201-6360kashah@novanthealth.org

Principal Investigator:

Alan P. Skarbnik

Novant Health Cancer Institute - Mooresville

Recruiting

Mooresville, North Carolina, United States, 28117

Contacts

Site Public Contact

980-201-6360kashah@novanthealth.org

Principal Investigator:

Alan P. Skarbnik

Novant Health Cancer Institute - Mount Airy

Recruiting

Mount Airy, North Carolina, United States, 27030

Contacts

Site Public Contact

336-718-8335asmarrs@novanthealth.org

Principal Investigator:

James P. Dugan

Novant Health Cancer Institute - Wilkesboro

Recruiting

North Wilkesboro, North Carolina, United States, 28659

Contacts

Site Public Contact

336-718-8335pjordan@novanthealth.org

Principal Investigator:

James P. Dugan

Rowan Regional Medical Center

Recruiting

Salisbury, North Carolina, United States, 28144

Contacts

Site Public Contact

704-210-5000nnechiporchik@novanthealth.org

Principal Investigator:

Alan P. Skarbnik

Novant Health Cancer Institute - Statesville

Recruiting

Statesville, North Carolina, United States, 28625

Contacts

Site Public Contact

336-718-8335pjordan@novanthealth.org

Principal Investigator:

James P. Dugan

Novant Health Cancer Institute - Thomasville

Recruiting

Thomasville, North Carolina, United States, 27360

Contacts

Site Public Contact

336-718-8335pjordan@novanthealth.org

Principal Investigator:

James P. Dugan

Novant Health Forsyth Medical Center

Recruiting

Winston-Salem, North Carolina, United States, 27103

Contacts

Site Public Contact

336-718-8335pjordan@novanthealth.org

Principal Investigator:

James P. Dugan

Wake Forest University Health Sciences

Recruiting

Winston-Salem, North Carolina, United States, 27157

Contacts

Site Public Contact

336-713-6771

Principal Investigator:

Rakhee Vaidya

OhioHealth O'Bleness Hospital

Recruiting

Athens, Ohio, United States, 45701

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

Columbus Oncology and Hematology Associates Inc

Recruiting

Columbus, Ohio, United States, 43214

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

Riverside Methodist Hospital

Recruiting

Columbus, Ohio, United States, 43214

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

Grant Medical Center

Recruiting

Columbus, Ohio, United States, 43215

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

Doctors Hospital

Recruiting

Columbus, Ohio, United States, 43228

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

Delaware Health Center-Grady Cancer Center

Recruiting

Delaware, Ohio, United States, 43015

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

Grady Memorial Hospital

Recruiting

Delaware, Ohio, United States, 43015

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

Columbus Oncology and Hematology Associates

Recruiting

Dublin, Ohio, United States, 43016

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

Dublin Methodist Hospital

Recruiting

Dublin, Ohio, United States, 43016

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

OhioHealth Mansfield Hospital

Recruiting

Mansfield, Ohio, United States, 44903

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

OhioHealth Marion General Hospital

Recruiting

Marion, Ohio, United States, 43302

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

OhioHealth Pickerington Methodist Hospital

Recruiting

Pickerington, Ohio, United States, 43147

Contacts

Site Public Contact

614-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

OhioHealth Westerville Medical Campus/Westerville Cancer Center

Recruiting

Westerville, Ohio, United States, 43082

Contacts

Site Public Contact

610-788-3860Jennifer.Sexton@ohiohealth.com

Principal Investigator:

Basem M. William

University of Oklahoma Health Sciences Center

Recruiting

Oklahoma City, Oklahoma, United States, 73104

Contacts

Site Public Contact

405-271-8777ou-clinical-trials@ouhsc.edu

Principal Investigator:

Taha Al-Juhaishi

Saint Charles Health System

Recruiting

Bend, Oregon, United States, 97701

Contacts

Site Public Contact

541-706-2909nosall@stcharleshealthcare.org

Principal Investigator:

Alison K. Conlin

Clackamas Radiation Oncology Center

Recruiting

Clackamas, Oregon, United States, 97015

Contacts

Site Public Contact

503-215-2614CanRsrchStudies@providence.org

Principal Investigator:

Alison K. Conlin

Bay Area Hospital

Recruiting

Coos Bay, Oregon, United States, 97420

Contacts

Site Public Contact

541-269-8392cherie.cox@bayareahospital.org

Principal Investigator:

Alison K. Conlin

Providence Hood River Memorial Hospital

Recruiting

Hood River, Oregon, United States, 97031

Contacts

Site Public Contact

503-215-1979canrsrchstudies@provdience.org

Principal Investigator:

Alison K. Conlin

Providence Newberg Medical Center

Recruiting

Newberg, Oregon, United States, 97132

Contacts

Site Public Contact

503-215-2614CanRsrchStudies@providence.org

Principal Investigator:

Alison K. Conlin

Providence Willamette Falls Medical Center

Recruiting

Oregon City, Oregon, United States, 97045

Contacts

Site Public Contact

503-215-2614CanRsrchStudies@providence.org

Principal Investigator:

Alison K. Conlin

Providence Portland Medical Center

Recruiting

Portland, Oregon, United States, 97213

Contacts

Site Public Contact

503-215-2614CanRsrchStudies@providence.org

Principal Investigator:

Alison K. Conlin

Providence Saint Vincent Medical Center

Recruiting

Portland, Oregon, United States, 97225

Contacts

Site Public Contact

503-215-2614CanRsrchStudies@providence.org

Principal Investigator:

Alison K. Conlin

Saint Charles Health System-Redmond

Recruiting

Redmond, Oregon, United States, 97756

Contacts

Site Public Contact

541-706-2909

Principal Investigator:

Alison K. Conlin

Christiana Care Health System-Concord Health Center

Recruiting

Chadds Ford, Pennsylvania, United States, 19317

Contacts

Site Public Contact

302-623-4450lbarone@christianacare.org

Principal Investigator:

Gregory A. Masters

Geisinger Medical Center

Recruiting

Danville, Pennsylvania, United States, 17822

Contacts

Site Public Contact

570-271-5251HemonCCTrials@geisinger.edu

Principal Investigator:

Joseph P. Lynch

Geisinger Wyoming Valley/Henry Cancer Center

Recruiting

Wilkes-Barre, Pennsylvania, United States, 18711

Contacts

Site Public Contact

570-271-5251HemonCCTrials@geisinger.edu

Principal Investigator:

Joseph P. Lynch

Medical University of South Carolina

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Site Public Contact

843-792-9321hcc-clinical-trials@musc.edu

Principal Investigator:

Ashwath Gurumurthi

Huntsman Cancer Institute/University of Utah

Recruiting

Salt Lake City, Utah, United States, 84112

Contacts

Site Public Contact

888-424-2100cancerinfo@hci.utah.edu

Principal Investigator:

Lauren Lee

University of Virginia Cancer Center

Recruiting

Charlottesville, Virginia, United States, 22908

Contacts

Site Public Contact

434-243-6303uvacancertrials@hscmail.mcc.virginia.edu

Principal Investigator:

Nathan L. Roberts

VCU Massey Comprehensive Cancer Center

Recruiting

Richmond, Virginia, United States, 23298

Contacts

Site Public Contact

804-628-6430CTOclinops@vcu.edu

Principal Investigator:

Sneha Purvey

Providence Regional Cancer System-Aberdeen

Recruiting

Aberdeen, Washington, United States, 98520

Contacts

Site Public Contact

360-412-8958deidre.dillon@providence.org

Principal Investigator:

Alison K. Conlin

PeaceHealth Saint Joseph Medical Center

Recruiting

Bellingham, Washington, United States, 98225

Contacts

Site Public Contact

360-788-8223achapman1@peacehealth.org

Principal Investigator:

Charles W. Drescher

Providence Regional Cancer System-Centralia

Recruiting

Centralia, Washington, United States, 98531

Contacts

Site Public Contact

360-412-8958deidre.dillon@providence.org

Principal Investigator:

Alison K. Conlin

Swedish Cancer Institute-Edmonds

Recruiting

Edmonds, Washington, United States, 98026

Contacts

Site Public Contact

206-215-2343PCRC-NCORP@Swedish.org

Principal Investigator:

Alison K. Conlin

Providence Regional Cancer Partnership

Recruiting

Everett, Washington, United States, 98201

Contacts

Site Public Contact

425-261-3529marilyn.birchman@providence.org

Principal Investigator:

Alison K. Conlin

Swedish Cancer Institute-Issaquah

Recruiting

Issaquah, Washington, United States, 98029

Contacts

Site Public Contact

206-215-2343PCRC-NCORP@Swedish.org

Principal Investigator:

Alison K. Conlin

Kadlec Clinic Hematology and Oncology

Recruiting

Kennewick, Washington, United States, 99336

Contacts

Site Public Contact

509-783-4637research@kadlecmed.org

Principal Investigator:

Alison K. Conlin

Providence Regional Cancer System-Lacey

Recruiting

Lacey, Washington, United States, 98503

Contacts

Site Public Contact

360-412-8958deidre.dillon@providence.org

Principal Investigator:

Alison K. Conlin

PeaceHealth Saint John Medical Center

Recruiting

Longview, Washington, United States, 98632

Contacts

Site Public Contact

360-514-2016kmakin-bond@peacehealth.org

Principal Investigator:

Alison K. Conlin

Skagit Regional Health Cancer Care Center

Recruiting

Mount Vernon, Washington, United States, 98274

Contacts

Site Public Contact

360-814-2182rcccclinicalresearch@skagitvalleyhospital.org

Principal Investigator:

Alison K. Conlin

Swedish Medical Center-Ballard Campus

Recruiting

Seattle, Washington, United States, 98107

Contacts

Site Public Contact

206-215-3086PCRC-NCORP@Swedish.org

Principal Investigator:

Alison K. Conlin

Swedish Medical Center-Cherry Hill

Recruiting

Seattle, Washington, United States, 98122-5711

Contacts

Site Public Contact

206-215-3086PCRC-NCORP@Swedish.org

Principal Investigator:

Alison K. Conlin

Swedish Medical Center-First Hill

Recruiting

Seattle, Washington, United States, 98122

Contacts

Site Public Contact

206-215-2343PCRC-NCORP@Swedish.org

Principal Investigator:

Alison K. Conlin

PeaceHealth United General Medical Center

Recruiting

Sedro-Woolley, Washington, United States, 98284

Contacts

Site Public Contact

360-788-8239achapman1@peacehealth.org

Principal Investigator:

Charles W. Drescher

Cancer Care Northwest - Spokane South

Recruiting

Spokane, Washington, United States, 99202

Contacts

Site Public Contact

509-228-1680research@ccnw.net

Principal Investigator:

Alison K. Conlin

Cancer Care Northwest-Valley

Recruiting

Spokane, Washington, United States, 99216

Contacts

Site Public Contact

509-228-1680research@ccnw.net

Principal Investigator:

Charles W. Drescher

Cancer Care Northwest-North Spokane

Recruiting

Spokane, Washington, United States, 99218

Contacts

Site Public Contact

509-228-1680research@ccnw.net

Principal Investigator:

Alison K. Conlin

PeaceHealth Southwest Medical Center

Recruiting

Vancouver, Washington, United States, 98664

Contacts

Site Public Contact

360-514-3940kmakin-bond@peacehealth.org

Principal Investigator:

Alison K. Conlin

Providence Saint Mary Regional Cancer Center

Recruiting

Walla Walla, Washington, United States, 99362

Contacts

Site Public Contact

509-897-5993Cheryl.Dodd@providence.org

Principal Investigator:

Alison K. Conlin

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Recruiting

Madison, Wisconsin, United States, 53718

Contacts

Site Public Contact

800-622-8922clinicaltrials@cancer.wisc.edu

Principal Investigator:

Priyanka Pophali

University of Wisconsin Carbone Cancer Center - University Hospital

Recruiting

Madison, Wisconsin, United States, 53792

Contacts

Site Public Contact

800-622-8922clinicaltrials@cancer.wisc.edu

Principal Investigator:

Priyanka Pophali

Marshfield Medical Center-Marshfield

Recruiting

Marshfield, Wisconsin, United States, 54449

Contacts

Site Public Contact

800-782-8581oncology.clinical.trials@marshfieldresearch.org

Principal Investigator:

Chady A. Leon

Froedtert Menomonee Falls Hospital

Recruiting

Menomonee Falls, Wisconsin, United States, 53051

Contacts

Site Public Contact

262-257-5100

Principal Investigator:

Kaitlin Annunzio

Medical College of Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Site Public Contact

414-805-3666

Principal Investigator:

Kaitlin Annunzio

ProHealth D N Greenwald Center

Recruiting

Mukwonago, Wisconsin, United States, 53149

Contacts

Site Public Contact

research.institute@phci.org

Principal Investigator:

Timothy R. Wassenaar

Froedtert and MCW Moorland Reserve Health Center

Recruiting

New Berlin, Wisconsin, United States, 53151

Contacts

Site Public Contact

414-805-0505

Principal Investigator:

Kaitlin Annunzio

Drexel Town Square Health Center

Recruiting

Oak Creek, Wisconsin, United States, 53154

Contacts

Site Public Contact

414-805-0505

Principal Investigator:

Kaitlin Annunzio

ProHealth Oconomowoc Memorial Hospital

Recruiting

Oconomowoc, Wisconsin, United States, 53066

Contacts

Site Public Contact

262-928-7878

Principal Investigator:

Timothy R. Wassenaar

ProHealth Waukesha Memorial Hospital

Recruiting

Waukesha, Wisconsin, United States, 53188

Contacts

Site Public Contact

262-928-7632

Principal Investigator:

Timothy R. Wassenaar

UW Cancer Center at ProHealth Care

Recruiting

Waukesha, Wisconsin, United States, 53188

Contacts

Site Public Contact

262-928-5539Chanda.miller@phci.org

Principal Investigator:

Timothy R. Wassenaar

Froedtert West Bend Hospital/Kraemer Cancer Center

Recruiting

West Bend, Wisconsin, United States, 53095

Contacts

Site Public Contact

414-805-0505

Principal Investigator:

Kaitlin Annunzio

More Information

Sponsor

Eastern Cooperative Oncology Group

Last update posted

Aug 19, 2026

Last verified

Jul, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Eastern Cooperative Oncology Group on 2026-08-19.