Recruiting

Intrapleural Saline Irrigation

Sponsor:

Beth Israel Deaconess Medical Center

Code:

NCT06727578

Conditions

Pleural Effusion Disorder

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

of intrapleural saline irrigation with CLR irrigator

Study Details

Brief summary:

Single-arm pilot trial of the use of intrapleural saline irrigation to treat retained pleural infections for patients with contraindications to standard of care intrapleural enzymatic therapy.

Conditions

Pleural Effusion Disorder

Study ID

NCT06727578

Start date

May 25, 2025

Status verified date

Aug, 2026

Completion date

Jul 31, 2027

Anticipated

Primary completion date

May 25, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Retained pleural effusion identified via bedside ultrasound within the first 24 hours after chest tube insertion
  • Patient is contraindicated from receiving intrapleural enzymatic therapy within the first 24 hours after chest tube insertion

Exclusion Criteria:

  • Non-infectious cause of pleural fluid analysis findings listed above identified (e.g. malignancy)
  • Post-procedural empyema or complicated parapneumonic effusion

Study Design

Enrollment

10 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Treatment

Interventions

of intrapleural saline irrigation with CLR irrigator

patients will have a CLRTM port and CLRTM irrigator (CLR Medical, Calverton, MD, USA) added to their chest tube and atrium circuit to facilitate pleural irrigation.

Primary outcome measure

  • Radiographic improvement (reduction in the ammount of pleural effusion messured in centimeters) by bed side ultrasound day 1,2,3,4,5. [ Time Frame: Daily for 8 days ]

Central Contacts and Locations

Central contacts

Christine Conley

617-632-8386Cconley@bidmc.harvard.edu

Locations

Beth Israel Deaconess Medical Center

Recruiting

Boston, Massachusetts, United States, 02215

More Information

Sponsor

Beth Israel Deaconess Medical Center

Last update posted

Aug 27, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Beth Israel Deaconess Medical Center on 2026-08-27.