Recruiting

Neurophysiological Markers

Sponsor:

The University of Texas at Dallas

Code:

NCT06731452

Conditions

Healthy Lifestyle

Health-Related Behavior

Eligibility Criteria

Sex: All

Age: 22 - 70+

Healthy Volunteers: Accepted

Interventions

Strategic Memory Advanced Reasoning Training teaches meta-cognitive strategies for individuals to apply to their daily lives for improved performance

Study Details

Brief summary:

The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been suggested as a promising brain imaging tool for identifying biomarkers of brain health.

In this pilot study, study investigators will explore the neurophysiological metrics of brain health with a non-invasive brain imaging technique, alongside behavioral and fMRI metrics collected through another study (NCT04869111).

Conditions

Healthy Lifestyle

Health-Related Behavior

Study ID

NCT06731452

Start date

Sep 3, 2025

Status verified date

Sep, 2025

Completion date

May 31, 2027

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 22 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Must be an active brain imaging participant in The BrainHealth Project (NCT04869111)
  • Minimum age of 22
  • Fluent in English
  • Able to read \& hear information over a computer
  • Must pass an MRI safety screener to assess the presence of contraindicators for MRI compatibility (i.e., non-removable metal within/on the body, claustrophobia, pregnancy, non-correctable vision problems, head trauma, and CNS disease)or other standard requirements as determined by the Imaging Center.
  • Must pass a modified TMS Adult Safety Screen
  • Meet all criteria for study as determined by the study physician

Exclusion Criteria:

  • A diagnosis of a neurodegenerative disease
  • A history of stroke, concussion, or brain injury that currently hinders them from functioning at their prior level
  • A diagnosis of autism spectrum disorder that currently hinders them from functioning independently.
  • Metallic brain implants or fragments (like a shunt, pacemaker, clips, coils, bullet fragments, cochlear implants)
  • Magnetically activated implants or electronically implanted devices
  • Medication pumps
  • Personal or family history of epilepsy, seizure(s), seizure disorder.
  • History of, or risk factors for syncope (fainting)
  • Report significant cognitive challenges
  • Report untreated health issues (like substance abuse, hypertension, hypo- or hyper-thyroidism)
  • Have claustrophobia

Study Design

Enrollment

63 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Online Strategic Memory Advanced Reasoning Training & Stress Solutions

Strategic Memory Advanced Reasoning Training (SMART) teaches meta-cognitive strategies for individuals to apply to their daily lives for improved performance Stress Solutions provides individuals with opportunities to extend the SMART principles to domains of stress and resilience.

Interventions

Strategic Memory Advanced Reasoning Training teaches meta-cognitive strategies for individuals to apply to their daily lives for improved performance

Online SMART is a curriculum that teaches strategies of how to use the brain better, in such a way that may improve brain health and performance. SMART strives to achieve optimal cognitive function realized by the brain's ability to efficiently manage complex information by abstracting its essential meaning rather than attempting to memorize details, and to prioritize the information in order to attend to the most relevant parts.

Stress Solutions extends the SMART principles to relevant domains of stress and resilience.

Primary outcome measure

  • Correlation of DELPHI-MD Output Measures with the online BrainHealth Index [ Time Frame: Up to one year ]

Central Contacts and Locations

Central contacts

Erin Venza, MS

972-883-3208erin.venza@utdallas.edu

Locations

Center for BrainHealth at The University of Texas at Dallas

Recruiting

Dallas, Texas, United States, 75235

Contacts

Erin Venza, MS

972-883-3208erin.venza@utdallas.edu

More Information

Sponsor

The University of Texas at Dallas

Last update posted

Sep 16, 2025

Last verified

Sep, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by The University of Texas at Dallas on 2025-09-16.