Observational StudyA Biorepository of Multiple Allergic Diseases (MADREP) With Longitudinal Follow-Up

• INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1)Aged 3 to 100 years.

2a) Suspected or confirmed allergic, atopic, respiratory, or nasal/sinus disorder or have suspected or confirmed history of an immune dysregulatory disorder, OR

2b) Have a clinical history of an immediate hypersensitivity reaction to aeroallergens, food, insect stings, or medications.

3\) Able to provide informed consent.

4\) Have or are willing to obtain a non-NIH primary physician who will manage all health conditions and be responsive for emergency medical treatment, if required.

5\) Willing to allow storage of blood, skin swabs, nasal fluid/brushings, bodily fluids, and other clinically appropriate tissue specimens or data generated during participation for future use in medical research.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this

study:

1. Any condition(s) or diagnosis, physical and/or psychological, that the investigator feels precludes the patient from participation in the study.
2. For additional skin biopsies only:

1. Individuals who have a history of keloid formation
2. Children (<18 years old)
3. Participants who are pregnant
3. For additional nasal-sinus polyp biopsies only:

1. Individuals on blood thinners unless they have already been stopped for the procedure
2. Children (<18 years old)
3. Participants who are pregnant
4. For skin prick testing

a. Participants who are pregnant.
5. Endoscopic Biopsy

1. Uncontrolled asthma or Grade 3 or higher by the American Society of Anesthesiologist's Physical Status Classification System (https://www.asahq.org/standards-and-practice-parameters/statement-on-asaphysical-status-classification-system)
2. History of adverse reaction to conscious sedation or general anesthesia required for endoscopy
3. Hemoglobin < 11 g/dL
4. Platelet count < 100,000 microL
5. Pregnant or breastfeeding
6. Severe hypoxemia due to chronic pulmonary disease
7. Recent abdominal surgery
8. Anticoagulant therapy that cannot be interrupted
9. Younger than 18 years of age

Participants will be selected in an equitable manner from the available pool of potentially eligible individuals, without regard to factors such as sex, gender, race, ethnicity, sexual orientation, or socioeconomic status.