Recruiting

Working Memory Training

Sponsor:

St. Joseph's Hospital and Medical Center, Phoenix

Code:

NCT06734286

Conditions

Mild Cognitive Impairment (MCI)

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Interventions

CogMed

Study Details

Brief summary:

The purpose of this study is to test whether a special memory training program, called CogMed, can help people with early memory problems. The Investigators want to see if this training improves memory and also helps reduce stress.

The Investigators also want to see if CogMed results in changes to a blood biomarker called p-Tau 217, which possibly indicate Alzheimer's disease (AD).

Conditions

Mild Cognitive Impairment (MCI)

Study ID

NCT06734286

Start date

Sep 16, 2024

Status verified date

Nov, 2024

Completion date

Sep 30, 2025

Anticipated

Primary completion date

Jun 30, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Male or female outpatients ages ≥ 50 years;
2. Meet Mayo Clinic Criteria for MCI. (Patients with mild cognitive impairment)
3. Access to the internet through computer
4. A proficiency in speaking and reading English or having a family member who is proficient in reading and speaking English and is willing to serve as a translator.
5. Vision and hearing must be sufficient to comply with study procedures.

Exclusion Criteria:

1. Mini Mental State Exam (MMSE) score less than 19 or patients diagnosed with moderate or severe dementia by a clinician.
2. In the opinion of the investigator, participation would not be in the best interest of the subject.

Study Design

Enrollment

10 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Intervention Group

The Intervention Group (N = 5) Participants will be instructed to do CogMed intervention (computerized working memory activity carried out for 25 minutes daily for 5 days per week for a total of 10 weeks).

no intervention: Control Group

The Control group(N = 5) follow there Treatment as usual(TAU). For ethical reasons, at the end of trial, the control group will also be offered the CogMed intervention.

Interventions

CogMed

CogMed which is a computerized working memory training program developed by Karolinska University.

Primary outcome measure

  • Working Memory as measured by the WAIS-IV Digit Span Forward/Backward [ Time Frame: Will be assessed at baseline and again at a 3-month follow-up following the intervention period. ]
  • Working Memory as measured by the TMT-B [ Time Frame: Will be assessed at baseline and again at a 3-month follow-up following the intervention period. ]
  • Working Memory as measured by Category Fluency Test [ Time Frame: Will be assessed at baseline and again at a 3-month follow-up following the intervention period. ]

Central Contacts and Locations

Central contacts

Yonas E Geda, M.D, MSc

833-233-3073yonas.geda@commonspirit.org

Geetika Chahal, MBBS

602-406-7240geetika.chahal@commonspirit.org

Locations

Barrow Neurological Institute, Division of Alzheimer's Disease

Recruiting

Phoenix, Arizona, United States, 85013

Contacts

Yonas E Geda, M.D, MSc

833-233-3073yonas.geda@commonspirit.org

Geetika Chahal, MBBS

602-406-7240Geetika.chahal@commonspirit.org

More Information

Sponsor

St. Joseph's Hospital and Medical Center, Phoenix

Last update posted

Dec 16, 2024

Last verified

Nov, 2024

Keywords

  • CogMed
  • Mild cognitive Impairment
  • CogMed intervention targeting working memory
  • CogMed Intervention Vs Treatment as Usual
  • working memory training
  • Alzheimer's Disease

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by St. Joseph's Hospital and Medical Center, Phoenix on 2024-12-16.