Recruiting

Pre-Dialysis Exercise

Sponsor:

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Code:

NCT06735378

Conditions

Hemodialysis

Cardioprotection

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Intradialytic Cycling

Study Details

Brief summary:

The goal of this study is to determine what happens to the heart muscle contraction when people cycle before their hemodialysis treatment. Will pre-dialysis exercise protect the heart from a decrease in pumping of the heart muscle (called stunning) that can happen during hemodialysis. We will study whether pre-dialysis exercise decreases heart stunning, decreases the number and severity of symptoms commonly associated with hemodialysis, and other outcomes

Conditions

Hemodialysis

Cardioprotection

Study ID

NCT06735378

Start date

Jan 20, 2025

Status verified date

Jan, 2025

Completion date

Dec 31, 2025

Anticipated

Primary completion date

Oct 31, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • must be on chronic hemodialysis for at least 3 months
  • age 18 years or older
  • willing and able to provide informed consent
  • assessed to be safe and able to exercise by unit HD Nephrologist

Exclusion Criteria:

  • regular vigorous exercise outside of hemodialysis
  • over 79 years of age
  • intradialytic exercise < 3 months
  • poor echogenicity
  • acute coronary syndrome in the past 3 months
  • unstable arrhythmia/angina
  • shortness of breath at rest or with minimal activity
  • symptomatic hypoglycemia (>2x/week in the week prior to enrolment)

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Randomization Order 1

Participants will be randomized into one of the two groups indicating the order in which they will receive the exercise intervention.

Randomization Order 1 will receive the exercise treatment on the first day of the first week of the study. The other three days without exercise will consist of standard dialysis sessions with study procedures.

experimental: Randomization Order 2

Participants will be randomized into one of the two groups indicating the order in which they will receive the exercise intervention.

Randomization Order 2 will receive the exercise treatment on the first day of the fourth week of the study. The other three days without exercise will consist of standard dialysis sessions with study procedures.

Interventions

Intradialytic Cycling

The impact of interdialytic exercise on cardio protection during HD has never been studied. This approach may enhance cardiovascular benefits and overall physical fitness, thereby contributing to better health outcomes in individuals undergoing HD.

Primary outcome measure

  • Change in the number of left ventricular segments undergoing a greater than 20% reduction in longitudinal strain as detected by echocardiogram [ Time Frame: week 1 to week 4 ]

Central Contacts and Locations

Central contacts

Jarrin Penny, PhD, RN, CNeph (C)

519-685-8500jarrin.penny@lhsc.on.ca

Kathy Koyle

519-685-8500kathleen.koyle@lhsc.on.ca

Locations

London Health Sciences Centre

Recruiting

London, Ontario, Canada, N6A 5W9

More Information

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Last update posted

Jan 22, 2025

Last verified

Jan, 2025

Keywords

  • Cardioprotection
  • Preconditioning Exercise
  • Hemodialysis

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's on 2025-01-22.