Recruiting

Wild Blueberries

Sponsor:

Georgia State University

Code:

NCT06735599

Conditions

Hypertension (Without Type 2 Diabetes Mellitus)

High Blood Pressure

Male

Female

Adult

Eligibility Criteria

Sex: All

Age: 45 - 65

Healthy Volunteers: Not accepted

Interventions

Wild Blueberry

Placebo

Study Details

Brief summary:

The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.

Conditions

Hypertension (Without Type 2 Diabetes Mellitus)

High Blood Pressure

Male

Female

Adult

Study ID

NCT06735599

Start date

Sep 17, 2024

Status verified date

Sep, 2026

Completion date

Jan 1, 2027

Anticipated

Primary completion date

Jan 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 45 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Individuals 45-65 years of age
  • Diagnosis of elevated blood pressure or stage 1 hypertension (systolic blood pressure = 120-139 mmHg and/or diastolic blood pressure = 80-89 mmHg) for at least 6 months
  • BMI 25-35 kg/m2 via anthropometric measurements.
  • Ability to give consent

Exclusion Criteria:

  • Allergies to berries
  • Use of one hypertensive drug for less than three months
  • Use of more than one anti-hypertensive or statin drug, insulin, antibiotics, and anti-inflammatory drugs, active cancer, gastrointestinal, renal, cardiovascular, thyroid, and neurological disorders or severe head injury
  • Smoking
  • Alcohol consumption (>2 drinks/day)
  • Consuming antioxidant, probiotic, and prebiotic supplements
  • Pregnant or lactating
  • Participating in a weight loss program

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Wild Blueberry

22 g of freeze-dried wild blueberry freeze-dried powder per day

placebo comparator: Placebo

22 g of freeze-dried macronutrient-matched placebo powder per day

Interventions

Wild Blueberry

Daily consumption of 22 g of freeze-dried wild blueberry freeze-dried powder for 8 weeks

Placebo

Daily consumption of 22 g of freeze-dried macronutrient-matched placebo powder for 8 weeks

Primary outcome measure

  • Ambulatory Blood Pressure [ Time Frame: Baseline, 4 weeks, and 8 weeks ]
  • Pulse Wave Velocity [ Time Frame: Baseline, 4 weeks, and 8 weeks ]

Central Contacts and Locations

Central contacts

Rafaela G Feresin, PhD

404-413-1233berries@gsu.edu

Locations

Georgia State University

Recruiting

Atlanta, Georgia, United States, 30303

Contacts

Rafaela Feresin, PhD

404-413-1233berries@gsu.edu

Principal Investigator:

Rafaela G Feresin, PhD

More Information

Sponsor

Georgia State University

Last update posted

Sep 2, 2026

Last verified

Sep, 2026

Keywords

  • Blueberries
  • Hypertension
  • Overweight
  • High Blood Pressure
  • Endothelial Function
  • Cognitive Function
  • Dietary intervention
  • functional foods
  • gut microbiota
  • arterial stiffness
  • microvascular function

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Georgia State University on 2026-09-02.