Recruiting

Blueberries

Sponsor:

Georgia State University

Code:

NCT06735651

Conditions

Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)

Female

Adult

Endothelial Function (Reactive Hyperemia)

Arterial Stiffness

Eligibility Criteria

Sex: Female

Age: 20 - 65

Healthy Volunteers: Not accepted

Interventions

Wild Blueberry

Placebo

Study Details

Brief summary:

The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.

Conditions

Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)

Female

Adult

Endothelial Function (Reactive Hyperemia)

Arterial Stiffness

Study ID

NCT06735651

Start date

Sep 20, 2024

Status verified date

Sep, 2026

Completion date

Sep 1, 2027

Anticipated

Primary completion date

Jun 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 20 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Women aged 20-65 years old
  • Prediabetes (fasting blood glucose 100-125 mg/dL and/or HbA1c percentage between 5.7-6.4)
  • Body Mass Index between 25-30 kg/m\^2

Exclusion Criteria:

  • Allergies to berries
  • Use of insulin, antidiabetic, antibiotics, and anti-inflammatory drugs
  • Active cancer, gastrointestinal, renal, thyroid, stage 1 \& 2 hypertension and other cardiovascular diseases, neurological diseases, or severe head injury
  • Smoking
  • Consumes greater than 2 alcoholic beverages per day
  • Consumes antioxidant, probiotic, and prebiotic supplements
  • Pregnant or Lactating
  • Actively participating in a weight loss program
  • Currently taking berry supplements or recently participated in another study taking berry supplements

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Wild Blueberry

22 g of freeze-dried wild blueberry freeze-dried powder per day

placebo comparator: Placebo

22 g of freeze-dried macronutrient-matched placebo powder per day

Interventions

Wild Blueberry

Daily consumption of 22 g of freeze-dried wild blueberry freeze-dried powder for 6 weeks

Placebo

Daily consumption of 22 g of freeze-dried macronutrient-matched placebo powder for 6 weeks

Primary outcome measure

  • Blood Glucose [ Time Frame: Baseline and 6 weeks ]
  • Ambulatory Blood Pressure [ Time Frame: Baseline and 6 weeks ]

Central Contacts and Locations

Central contacts

Rafaela G Feresin, PhD

404-413-1233berries@gsu.edu

Locations

Georgia State University

Recruiting

Atlanta, Georgia, United States, 30303

Contacts

Rafaela G Feresin, PhD

404-413-1233berries@gsu.edu

Principal Investigator:

Rafaela G Feresin, PhD

More Information

Sponsor

Georgia State University

Last update posted

Sep 2, 2026

Last verified

Sep, 2026

Keywords

  • Blueberries
  • Prediabetes
  • Insulin Resistance
  • Functional foods
  • Dietary intervention
  • Endothelial function
  • Vascular function
  • Cardiovascular health
  • Metabolic health
  • Gut microbiota
  • Cognitive function
  • Type II diabetes
  • Microvascular Function
  • Wild Blueberries

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Georgia State University on 2026-09-02.