Recruiting

Observational Study

Sponsor:

The Miriam Hospital

Code:

NCT06747000

Conditions

Lipid Disorders

Eligibility Criteria

Sex: All

Age: 18 - 69

Healthy Volunteers: Accepted

Study Details

Brief summary:

This study looks at how lipoproteins, which are particles in the blood that transport cholesterol, influence heart and blood vessel health. Beyond just their levels, the way these particles function plays a key role in preventing or contributing to disease. In some conditions, like high cholesterol or diabetes, lipoproteins may not work properly, increasing the risk of clogged arteries and other complications.

The investigators aim to study these changes in people with lipid disorders to better understand their impact on blood health and to find new ways to prevent and treat heart disease.

Conditions

Lipid Disorders

Study ID

NCT06747000

Start date

Jul 18, 2024

Status verified date

Sep, 2025

Completion date

Jul 18, 2029

Anticipated

Primary completion date

Jul 18, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 69

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Healthy volunteers
  • Abnormalities in lipid panels
  • Able to provide informed consent
  • Between the age of 18 and 69

Exclusion Criteria:

  • Drug or alcohol abuse within 6 months or significant mental/psychological impairment
  • Current smokers
  • Subjects with known bleeding disorders (for example, hemophilia)
  • Subjects requiring regular transfusions for any reason
  • No ethnic/racial groups will be excluded

Study Design

Enrollment

80 participants

Anticipated

Interventions and Outcome Measures

Arms

Individuals with lipid disorders

Individuals with lipid disorders (elevated HDL and LDL)

Healthy individuals

Healthy individuals with normal lipid values and without lipid-related diseases

Primary outcome measure

  • Percentage of platelet aggregation [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

Wenliang Song, MD

4014449851WSong@brownhealth.org

Daria Salamevich

7343588165DSalamevich@brownhealth.org

Locations

Brown University Health Lipid Clinic

Recruiting

East Providence, Rhode Island, United States, 02914

Contacts

Wenliang Song, MD

4014449851WSong@brownhealth.org

Daria Salamevich

7343588165DSalamevich@brownhealth.org

Principal Investigator:

Wenliang, MD

Cardiovascular Research Center

Recruiting

Providence, Rhode Island, United States, 02903

Contacts

Wenliang Song, MD

4014449851WSong@brownhealth.org

Daria Salamevich, MD

7343588165dsalamevich@lifespan.org

Principal Investigator:

Wenliang Song, MD

More Information

Sponsor

The Miriam Hospital

Last update posted

Oct 1, 2025

Last verified

Sep, 2025

Keywords

  • lipids
  • lipoproteins
  • platelets
  • high cholesterol

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by The Miriam Hospital on 2025-10-01.