Recruiting

Mobile TMS

Sponsor:

Medical University of South Carolina

Code:

NCT06748209

Conditions

Treatment Resistant Major Depression

Eligibility Criteria

Sex: All

Age: 22 - 70+

Healthy Volunteers: Not accepted

Interventions

Left prefrontal Transcranial Magnetic Stimulation (TMS)

FDA cleared TMS for treating depression

Study Details

Brief summary:

In this pilot study, investigators propose to design and create a portable TMS unit, in a van, and then test out delivering TMS in three different locations in South Carolina, all affiliated with MUSC and within 2-hours driving from Charleston, SC. This study would test out this new delivery mode, and provide valuable feasibility, safety, and efficacy lessons for later refinement and potential widespread adoption of mobile TMS as a treatment option, both in our state and across the US.

Conditions

Treatment Resistant Major Depression

Study ID

NCT06748209

Start date

May 10, 2025

Status verified date

May, 2026

Completion date

Mar 1, 2028

Anticipated

Primary completion date

Mar 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 22 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult (22-80 years old)
  • Have treatment-resistant depression as defined by the e-Mini, and the antidepressant treatment history form (ATHF short).
  • Be able to read and communicate in English.
  • Able to provide their own consent.
  • Access to a computer with videoconferencing ability for initial consent and telescreen.

Exclusion Criteria:

  • Patients with unstable medical conditions that might make TMS unsafe. This includes current poorly controlled seizures.
  • Ferromagnetic metal in the head.
  • Pregnant.
  • Currently active substance abuse except tobacco.

Study Design

Enrollment

30 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

other: Open label Clinical TMS for Depression

This will be FDA approved Left Prefrontal TMS for treating depression, we will be performing this within a VA, located at clinics throughout SC.

Interventions

Left prefrontal Transcranial Magnetic Stimulation (TMS)

FDA cleared TMS

FDA cleared TMS for treating depression

This is FDA approved TMS

Primary outcome measure

  • Percent of depression responders [ Time Frame: From baseline to 1 week immediately after treatment week ]
  • Improvement in Depression Symptoms [ Time Frame: From baseline to 1 week immediately after treatment week ]

Central Contacts and Locations

Central contacts

Mark S George, MD

8438765142GEORGEM@MUSC.EDU

Alexandra Herron, BA

herronal@musc.edu

Locations

Medical Univerity of South Carolina

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Mark S. George, MD

8438765142GEORGEM@MUSC.EDU

More Information

Sponsor

Medical University of South Carolina

Last update posted

May 6, 2026

Last verified

May, 2026

Keywords

  • Anxiety
  • Depression

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Medical University of South Carolina on 2026-05-06.