Recruiting
Phase 2

DAANCE

Sponsor:

Ohio State University Comprehensive Cancer Center

Code:

NCT06749210

Conditions

Cancer of the Breast

Chemotherapy-induced Neuropathy

Eligibility Criteria

Sex: All

Age: 40+

Healthy Volunteers: Not accepted

Interventions

Tango

Study Details

Brief summary:

Up to 80% of breast cancer survivors experience chemotherapy-induced neuropathy that impairs quality of life and increases fall risk long into survivorship, yet treatment options for neuropathy remain limited. The successful treatment will target neurophysiologic mechanisms for restoring function while addressing patient-reported symptoms and participation in treatment. Toward this end, the investigators propose to study a noninvasive, social sensorimotor intervention - Adapted Argentine Tango - which targets motor control restoration, symptom alleviation, and treatment participation in concert.

Conditions

Cancer of the Breast

Chemotherapy-induced Neuropathy

Study ID

NCT06749210

Start date

Feb 19, 2025

Status verified date

Jul, 2025

Completion date

Aug 15, 2029

Anticipated

Primary completion date

Aug 15, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Breast Cancer (BC) diagnosis of Stage I-IV including metastatic disease
  • completed taxane-based chemotherapy for BC at least 3 months ago (no limit on how long ago)
  • symptomatic for chemotherapy-induced neuropathy (self-report)
  • postural control score that indicates potential fall-risk
  • able to understand and comply with directions associated with testing and study treatments

Exclusion Criteria:

  • pre-existing vestibular dysfunction
  • poorly controlled diabetes (hgA1C>=8)
  • non-ambulatory (assistive and prosthetic devices allowed)
  • hearing impairment resulting in less than 10% hearing bilaterally
  • contraindication to participate in the experimental physical activity per the treating oncologist due to additional condition (e.g., herniated disc, unstable bone metastases)
  • currently in activity-based therapy (e.g., physical therapy, occupational therapy). May enroll if still meet eligibility criteria once activity-based therapy is complete.

Study Design

Enrollment

140 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

no intervention: Control

4 weeks of usual care followed by optional 1-way crossover to 8 weeks of Intervention (partnered, adapted tango dance)

experimental: Experimental

8 weeks of intervention (partnered, adapted tango dance)

Interventions

Tango

The intervention being studied is a 16 session intervention (2x4-week modules), delivered over an 8-week period by community-based individuals with expertise in dance and patient care and certified in Adapted Tango or AdapTango dance instruction. Steps available to teach, including order and cues to teach them, are detailed in Hackney's AdapTango manual. All steps are based on the Argentine Tango steps that emerged within working class community centers in Buenos Aires, Argentina (milongas) in the late 1800s and have been adapted by the investigators for use as medical exercise among people with mobility deficits. Of note, Argentine Tango is distinct from, and the precursor for, the American Tango style of competitive ballroom dance: where American Tango highlights showmanship and complicated footwork, Argentine Tango prioritizes connection between partners and musicality within a basic walk motion.

Primary outcome measure

  • Patient-Reported Outcome (PRO) - CIN sensation [ Time Frame: 4 weeks ]
  • Dual-task function [ Time Frame: 4 weeks ]

Central Contacts and Locations

Central contacts

Lise Worthen-Chaudhari, PhD, MFA, CMES

(1) + 614-293-6281lise.worthen-chaudhari@osumc.edu

Locations

Yale University

Recruiting

New Haven, Connecticut, United States, 06520

Contacts

Maryam Lustberg, MD, MPH

maryam.lustberg@yale.edu

Principal Investigator:

Maryam Lustberg, MD, MPH

The Ohio State University

Recruiting

Columbus, Ohio, United States, 43220

Contacts

Lise Worthen-Chaudhari, PhD, MFA, CMES

(1) + 614-293-6281lise.worthen-chaudhari@osumc.edu

Principal Investigator:

Lise Worthen-Chaudhari, PhD, MFA, CMES

More Information

Sponsor

Ohio State University Comprehensive Cancer Center

Last update posted

Nov 5, 2025

Last verified

Jul, 2025

Keywords

  • survivorship
  • music
  • dance

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Ohio State University Comprehensive Cancer Center on 2025-11-05.