Recruiting

Observational Study

Sponsor:

Old Dominion University

Code:

NCT06763562

Conditions

Glucose Metabolism Disorders

Hunger

Fat Burn

Eligibility Criteria

Sex: All

Age: 18 - 70

Healthy Volunteers: Accepted

Interventions

Carbohydrate-first meal

Carbohydrate-last meal

Study Details

Brief summary:

Consuming a carbohydrate-rich food as the final food in a meal, as compared to the first food in a meal, has been shown to reduce blood glucose levels after eating in both diabetes patients and in healthy controls. However, gaps remain in the literature in this area of research, and currently little is known about how substrate (fuel) use is impacted by altering food order. In addition, most studies to date have used a mix of meat and plant foods, while little research has focused exclusively on vegetarian foods. This randomized experiment will examine how altering the order of foods eaten in a vegetarian meal impacts blood glucose and fuel utilization at rest.

Conditions

Glucose Metabolism Disorders

Hunger

Fat Burn

Study ID

NCT06763562

Start date

Jan 5, 2025

Status verified date

Jan, 2025

Completion date

Jun 30, 2026

Anticipated

Primary completion date

Jun 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18-70 years old
  • Free from any allergy or condition that precluding consumption of edamame, butter, and rice
  • Not currently pregnant
  • Free of any medical conditions requiring the use of insulin
  • Have no history of bariatric surgery
  • Have no implanted electrical devices such as a pacemaker

Exclusion Criteria:

  • Younger than 18 and older than 70 years old
  • Having an allergy or condition that precludes consumption of edamame, butter, and rice
  • Currently pregnant
  • Any medical conditions requiring the use of insulin
  • A history of bariatric surgery
  • Having an implanted electrical device such as a pacemaker

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Carbohydrate-first meal

experimental: Carbohydrate-last meal

Interventions

Carbohydrate-first meal

Rice eaten first (150 grams), followed by edamame (150 grams) and butter (10 grams)

Carbohydrate-last meal

Edamame (150 grams) and butter (10 grams) eaten first, followed by rice (150 grams)

Primary outcome measure

  • Respiratory exchange ratio [ Time Frame: 90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal) ]

Central Contacts and Locations

Central contacts

Locations

Old Dominion University Human Performance Laboratory

Recruiting

Norfolk, Virginia, United States, 23529

Contacts

Patrick Wilson, PhD

pbwilson@odu.edu

More Information

Sponsor

Old Dominion University

Last update posted

Feb 19, 2025

Last verified

Jan, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Old Dominion University on 2025-02-19.