Recruiting

Physical Activity

Sponsor:

University of South Carolina

Code:

NCT06768762

Conditions

Knee Replacement

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Phone Coaching

Progress reports to providers

'Hear from Others' Videos

Individualized Feedback

Online exercise program

Study Details

Brief summary:

The purpose of this study is to identify which supplemental intervention components added to an online exercise program contribute to the greatest increases in physical activity (total MVPA and percent meeting guidelines \[≥150 min/week of MVPA\]) in adults with knee replacement at 6 and 12 months. Secondary outcomes will examine changes in pain and physical function.

Conditions

Knee Replacement

Study ID

NCT06768762

Start date

Jan 21, 2025

Status verified date

Apr, 2026

Completion date

Jul 31, 2029

Anticipated

Primary completion date

Dec 30, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • had a knee replacement (including primary, staged or independent bilateral, or revision) at least 12 months ago
  • have a computer, tablet, or smartphone with active internet access
  • self-report engaging in less than 60 minutes/week of moderate-intensity physical activity
  • be English-speaking and able to read consent and study materials written in English
  • be willing to complete the 4 remote assessments, including physical activity monitoring
  • be willing to be randomized to receive 0-4 supplemental intervention components.

Exclusion Criteria:

  • any contraindications to physical activity (e.g., chest pain)
  • have a scheduled surgery within the next 12 months (e.g., hip or knee replacement)
  • have a mobility limiting comorbidity unrelated to knee replacement
  • live outside of the continental U.S
  • do not currently have a physician or orthopedic surgeon whom they see regularly
  • are currently participating in physical therapy (for knee)
  • are participating in a structured weight loss or physical activity program
  • unable to provide proof of knee replacement surgery
  • have a BMI >40kg/m2
  • score >30 on PROMIS cognitive function

Study Design

Enrollment

336 participants

Anticipated

Allocation

Randomized

Intervention Model

Factorial

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Experimental condition 1

Energize Online Program plus phone coaching, progress reports to physicians, 'Hear From Others' videos, and individualized feedback

experimental: Experimental condition 2

Energize Online Program plus phone coaching, progress reports to physicians, and 'Hear From Others' videos

experimental: Experimental condition 3

Energize Online Program plus phone coaching, progress reports to physicians, and individualized feedback

experimental: Experimental condition 4

Energize Online Program plus phone coaching and progress reports to physicians

experimental: Experimental condition 5

Energize Online Program plus phone coaching, 'Hear From Others' videos, and individualized feedback

experimental: Experimental condition 6

Energize Online Program plus phone coaching and 'Hear From Others' videos

experimental: Experimental condition 7

Energize Online Program plus phone coaching and individualized feedback

experimental: Experimental condition 8

Energize Online Program plus phone coaching

experimental: Experimental condition 9

Energize Online Program plus progress reports to physicians, 'Hear From Others' videos, and individualized feedback

experimental: Experimental condition 10

Energize Online Program plus progress reports to physicians and 'Hear From Others' videos

experimental: Experimental condition 11

Energize Online Program plus progress reports to physicians and individualized feedback

experimental: Experimental condition 12

Energize Online Program plus progress reports to physicians

experimental: Experimental condition 13

Energize Online Program plus 'Hear From Others' videos and individualized feedback

experimental: Experimental condition 14

Energize Online Program plus 'Hear From Others' videos

experimental: Experimental condition 15

Energize Online Program plus individualized feedback

experimental: Experimental condition 16

Energize Online Program

Interventions

Phone Coaching

Participants will receive 11 coaching calls with a health coach. Calls will occur weekly during the first month, twice/month during months 2-3, and once/month during months 4-6. Each call is expected to last 10-15 minutes.

Progress reports to providers

Progress reports on physical activity and program adherence will be sent to participants providers at 3 and 6 months.

'Hear from Others' Videos

Participants will receive monthly 'Hear From Others' videos. The videos will include other adults with knee replacement discussing the challenges they have faced and strategies to overcome barriers to activity.

Individualized Feedback

Participants will receive individualized feedback from a coach via email. The feedback will specifically focus on participant responses to the 'Apply Your Knowledge' activities and will correspond with the video lessons. Feedback will be weekly during months 1-3 and monthly during months 4-6.

Online exercise program

MOST Energized! Online Exercise Program

Primary outcome measure

  • Physical activity (min/week) [ Time Frame: Baseline to 6 months ]
  • Percentage meeting physical activity guidelines [ Time Frame: 6 months ]
  • Physical activity (min/week) [ Time Frame: Baseline to 12 months ]
  • Percentage meeting physical activity guidelines [ Time Frame: 12 months ]

Central Contacts and Locations

Central contacts

Jakob Nelson, MS

803-766-6960JAKOBRN@email.sc.edu

Christine Pellegrini, PhD

803-777-0911pellegca@mailbox.sc.edu

Locations

University of South Carolina

Recruiting

Columbia, South Carolina, United States, 29208

Contacts

Christine Pellegrini

803-777-0911pellegca@mailbox.sc.edu

More Information

Sponsor

University of South Carolina

Last update posted

May 5, 2026

Last verified

Apr, 2026

Keywords

  • knee replacement
  • exercise
  • online

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of South Carolina on 2026-05-05.