Recruiting

Observational Study

Sponsor:

Northwestern University

Code:

NCT06769464

Conditions

Odor Intensity Ratings

Eligibility Criteria

Sex: All

Age: 12 - 65

Healthy Volunteers: Not accepted

Interventions

odor

Study Details

Brief summary:

Investigating representations of odor intensity in human piriform cortex. To identify a neural representation of perceived odor intensity, it is necessary to dissociate stimulus concentration from perceived intensity. Experiments for this aim will measure human perceptual responses while manipulating intensity independently from concentration using two complementary approaches. In Experiment 1A, we will match perceived intensities across odors of different concentrations, allowing us to identify a neural representation of intensity that is independent of stimulus identity and concentration. In Experiment 1B, we will create conditions of different perceived intensity over constant odor stimuli using adaptation. Approaching the same question from different angles will strengthen the robustness of our findings. Preliminary data suggest that temporal features of the piriform neural response may represent odor intensity.

Conditions

Odor Intensity Ratings

Study ID

NCT06769464

Start date

Apr 1, 2024

Status verified date

May, 2026

Completion date

Aug 1, 2028

Anticipated

Primary completion date

Apr 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 12 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Ages 12 to 65, english speaker, patients undergoing brain surgery for treatment of medically intractable epilepsy

Exclusion Criteria:

  • screening for history of smell or taste problems

Study Design

Enrollment

28 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Investigating representations of odor intensity in human piriform cortex.

Odors will be presented at different concentrations.

Interventions

odor

present odor

Primary outcome measure

  • Perceived odor intensity [ Time Frame: 15 minutes ]

Central Contacts and Locations

Central contacts

Locations

Northwestern University

Recruiting

Chicago, Illinois, United States, 60611

Contacts

More Information

Sponsor

Northwestern University

Last update posted

Aug 18, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Northwestern University on 2026-08-18.