Recruiting
Early Phase 1

Observational Study

Sponsor:

University of Missouri-Columbia

Code:

NCT06787066

Conditions

Menopause

Eligibility Criteria

Sex: Female

Age: 18 - 70

Healthy Volunteers: Accepted

Interventions

Propranolol Hydrochloride

Phentolamine Injection

Study Details

Brief summary:

The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.

Conditions

Menopause

Study ID

NCT06787066

Start date

Jul 10, 2025

Status verified date

Sep, 2025

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 70

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Assigned female at birth
  • 18-70 years of age
  • Body mass index (BMI) <30 kg/m2

Exclusion Criteria:

  • Assigned male at birth
  • Pregnancy, breastfeeding
  • Body mass index ≥30 kg/m2
  • Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy
  • Current smoking/nicotine use
  • Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
  • Nerve/neurologic disease
  • Cardiovascular, hepatic, renal, respiratory disease
  • Blood pressure ≥140/90 mmHg
  • Diabetes, Polycystic ovarian syndrome
  • Communication barriers
  • Prescription medications

Study Design

Enrollment

75 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

other: Women

Women ages 18-70 years will participate.

Interventions

Propranolol Hydrochloride

Examine how IV propranolol impacts sympathetic transduction

Phentolamine Injection

Examine how IV phentolamine impacts sympathetic transduction

Primary outcome measure

  • Sympathetic transduction [ Time Frame: 1 day (single study visit) ]

Central Contacts and Locations

Central contacts

Jacqueline Limberg, PhD

573-882-2420limbergj@missouri.edu

Locations

University of Missouri

Recruiting

Columbia, Missouri, United States, 65211

Contacts

Jacqueline Limberg

573-882-2544limbergj@missouri.edu

More Information

Sponsor

University of Missouri-Columbia

Last update posted

Sep 15, 2025

Last verified

Sep, 2025

Keywords

  • Menopause
  • Sympathetic nerve activity
  • Sympathetic transduction
  • Blood flow
  • Women&#39;s health
  • Blood pressure

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Missouri-Columbia on 2025-09-15.