Recruiting

Nasal vs. Oral

Sponsor:

University of Pennsylvania

Code:

NCT06789770

Conditions

Sleep Apnea, Obstructive

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This project will provide important new information regarding (1) the relationship between route of breathing and airway collapsibility and (2) whether route of breathing during DISE (Drug-Induced Sleep Endoscopy) is representative of natural sleep.

Conditions

Sleep Apnea, Obstructive

Study ID

NCT06789770

Start date

Nov 20, 2024

Status verified date

Mar, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • • Adults (≥ 18yrs) that underwent clinical evaluation at the CPAP Alternatives Clinic at Penn Otorhinolaryngology.

  • Must have at least mild OSA (AHI>5)

Exclusion Criteria:

  • • Sleep study with an AHI<5, >25% of total events being central or mixed events, or inability to achieve adequate drug-induced sleep.

  • Upper Respiratory Illness at the time of the DISE.

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Classification of route of breathing and upper airway collapsibility during Drug-induced Sleep Endoscopy (DISE) [ Time Frame: Within 3 months of enrollment ]

Central Contacts and Locations

Central contacts

Everett Seay

215-662-2777seaye@pennmedicine.upenn.edu

Michael Nichols

nicholsm@pennmedicine.upenn.edu

Locations

Hospital at the University of Pennsylvania

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Rafa Khan

215-615-8777khanr@pennmedicine.upenn.edu

Everett Seay

(215) 615-8777everett.seay@pennmedicine.upenn.edu

Principal Investigator:

Julianna Rodin, MD

More Information

Sponsor

University of Pennsylvania

Last update posted

Mar 13, 2026

Last verified

Mar, 2026

Keywords

  • breathing route
  • OSA
  • nasal breathing
  • oral breathing

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Pennsylvania on 2026-03-13.