Recruiting

Strength Training

Sponsor:

Queens College, The City University of New York

Code:

NCT06812143

Conditions

Aging

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Accepted

Interventions

Strength training

Strength training

Study Details

Brief summary:

The objective of the current study is to determine whether lifting lighter loads close to failure improves strength training adaptations and function in older adults. The main questions it aims to answer are:

1. The effect of light loads on physical function
2. The effect of light loads on muscle mass, power, and strength

Researchers will compare a light-load, high-repetition program to a standard strength training program. Participants will perform supervised strength training twice per week for 20 weeks.

Conditions

Aging

Study ID

NCT06812143

Start date

Feb 5, 2025

Status verified date

Feb, 2025

Completion date

Jan 25, 2027

Anticipated

Primary completion date

Dec 25, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Males and females aged 65 years and above
  • Inactive lifestyle (< 150 min per week of moderate intensity physical activity) and not regularly participating in a structured strength training program
  • Planning to reside in the area for the duration of the study

Exclusion Criteria:

  • Severe cardiac disease, including Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
  • Lung disease requiring either oral or injected steroids, or the use of supplemental oxygen
  • Short, portable mental status questionnaire with 3 or more errors
  • Severe arthritis (either osteoarthritis or rheumatoid arthritis)
  • Cancer requiring treatment in the past 1 year (melanomas excluded)
  • Development of chest pain or severe shortness of breath during the 6 min self-paced walk test
  • Parkinson's disease or other serious neurological disorders
  • Renal disease requiring dialysis
  • Current diagnosis of schizophrenia, other psychotic disorders, or bipolar disorder
  • Current consumption of more than 14 alcoholic drinks per week
  • Severe lower back or shoulder pain that may worsen with weightlifting exercises
  • Undergoing physical therapy involving the lower extremities
  • Living in nursing homes, assisted living facilities or other similar institutions
  • Currently enrolled in another randomized trial involving a pharmaceutical or lifestyle intervention
  • Weight change (intentional or not) over the last 6 months of > 5% of body weight, or plan to lose or gain weight during the study
  • Any other cardiovascular, pulmonary, orthopedic, neurologic, or other conditions that would preclude participation and successful completion of the protocol

Temporary Exclusion Criteria

A person meeting any of the following temporary exclusion criteria at the time of screening will not be enrolled but may be re-screened later.

  • Severe hypertension, e.g., SBP > 200 mm Hg, DBP > 110 mm Hg
  • Major surgery or fracture or hip/knee replacement within the last 6 months
  • Hospitalization within the last 6 months (excluding ER visits)

Study Design

Enrollment

68 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Light Load, High Repetition (LLHR)

The LLHR group will perform a full-body routine with lighter weights, performing 16-20 repetitions per set, close to failure.

active comparator: Strength Training (ST)

The ST group will perform a full-body routine with higher weights, performing 8-12 repetitions per set, close to failure.

Interventions

Strength training

This intervention involves strength training with lighter loads and higher repetitions.

Strength training

This intervention involves conventional strength training with higher loads and moderate repetitions.

Primary outcome measure

  • 6-minute walk test [ Time Frame: Baseline and week 21 ]

Central Contacts and Locations

Central contacts

Anoop T Balachandran, PhD

718-997-2729athozhuthungalba@qc.cuny.edu

Locations

Exercise & Aging Lab, Queens College

Recruiting

Flushing, New York, United States, 11367

Contacts

Anoop T Balachandran

718-570-0639athozhuthungalba@qc.cuny.edu

More Information

Sponsor

Queens College, The City University of New York

Last update posted

Jul 30, 2025

Last verified

Feb, 2025

Keywords

  • Strength training
  • Older adults
  • physical function

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Queens College, The City University of New York on 2025-07-30.