Recruiting

Observational Study

Sponsor:

University of British Columbia

Code:

NCT06819969

Conditions

Small Airways Diseases

Vaping

Vaping Related Disorder

Vaping Teens

Vaping Behavior

Eligibility Criteria

Sex: All

Age: 12+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Vaping is increasingly popular with both adolescent and adult Canadians, but the long-term health impacts remain unknown. We believe that the tools we currently have to detect lung disease in people who vape may be insufficient and propose new ways to find lung injuries that may impact them over the course of their lives. These include exercise testing, new imaging techniques, and new breathing tests that will demonstrate how vaping may harm their lungs. We will use these tools in both adolescent and adult Canadians to give Canadians who vape important information on the consequences of vaping.

Conditions

Small Airways Diseases

Vaping

Vaping Related Disorder

Vaping Teens

Vaping Behavior

Study ID

NCT06819969

Start date

Jul 25, 2025

Status verified date

Mar, 2026

Completion date

Dec 31, 2029

Anticipated

Primary completion date

Dec 31, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 12+

Healthy Volunteers: Accepted

Inclusion Criteria:

Adolescent arm:

  • Aged ≥12 and <19 years old
  • Either 1) use neither combustible cigarettes nor e-cigarettes or 2) use e-cigarettes exclusively

Adult arm:

  • Aged ≥19 years old
  • Fall into one of the following categories: 1) use neither combustible cigarettes nor e-cigarettes; 2) use combustible cigarettes exclusively, never using e-cigarettes; 3) use e-cigarettes exclusively, never using combustible cigarettes; or 4) use both combustible cigarettes and e-cigarettes currently

Exclusion Criteria:

Adolescent arm:

  • Contraindication to pulmonary function testing and cardiopulmonary exercise testing
  • Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of >1 joint-year
  • Have smoked combustible cigarettes within the last 6 months
  • Have a physician-diagnosed chronic lung disease (such as asthma, cystic fibrosis, or bronchopulmonary dysplasia)
  • Inability to provide written informed consent

Adult arm:

  • Contraindication to pulmonary function testing and cardiopulmonary exercise testing
  • Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of >1 joint-year
  • Currently undergoing treatment for lung cancer
  • Inability to provide written informed consent

No limitations will be placed on the type of e-liquids used by participants; e.g., e-cigarette users of nicotine, tetrahydrocannabinol, and cannabidiol will be all enrolled.

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Arms

Adults

Canadian adults aged 19 years or older. We will be enrolling e-cigarette-only users, non-e-cigarette and non-combustible cigarette users, combustible cigarette-only users, and dual combustible cigarette-e-cigarette users.

Adolescents

Canadian adolescents aged between 12 and <19 years, inclusive. We will be enrolling e-cigarette-only users, as well as non-e-cigarette and non-combustible cigarette users.

Primary outcome measure

  • Composite Measure of Small Airways Dysfunction [ Time Frame: From enrollment (Baseline) to the end of study participation (36 Months). ]

Central Contacts and Locations

Central contacts

Janice Leung, MD

604-836-0423janice.leung@hli.ubc.ca

Paloma Burns, MSc

604-442-7021pburns@providencehealth.bc.ca

Locations

University of Alberta (Clinical Sciences Building)

Recruiting

Edmonton, Alberta, Canada, T6G 2B7

Contacts

Michael Stickland

(780) 492-1657mks2@ualberta.ca

Desi Fuhr

fuhr@ualberta.ca

BC Cancer Agency

Recruiting

Vancouver, British Columbia, Canada, V5Z 4E6

Contacts

Stephen Lam

604-675-8094slam2@bccancer.bc.ca

Sukhinder Khattra

skhattra@bccancer.bc.ca

BC Children's Hospital Research Institute

Recruiting

Vancouver, British Columbia, Canada, V6H 3N1

Contacts

Jonathan Rayment

604-875-2345jonathan.rayment@bcchr.ca

Alireza Mojibian

alireza.mojibian@bcchr.ca

St. Paul's Hospital

Recruiting

Vancouver, British Columbia, Canada, V6Z 1Y6

Contacts

Janice Leung

604-836-0423janice.leung@hli.ubc.ca

Paloma Burns

604-442-7021pburns@providencehealth.bc.ca

Principal Investigator:

Janice Leung

University of Ottawa (The Ottawa Hospital General Campus)

Recruiting

Ottawa, Ontario, Canada, K1H 8L6

Contacts

Shawn Aaron

613-737-8899saaron@ohri.ca

Kathy Vandemheen

kvandemheen@toh.ca

More Information

Sponsor

University of British Columbia

Last update posted

Mar 30, 2026

Last verified

Mar, 2026

Keywords

  • CLOUD
  • small airway injury
  • vaping
  • vape
  • e-cigarette
  • oscillometry
  • multiple breath washout
  • chest computed tomography
  • chest CT
  • hyperpolarized 129-xenon
  • MRI
  • CPET
  • bronchoscopy
  • transcriptomics
  • epigenetics

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of British Columbia on 2026-03-30.