Recruiting

Wild Blueberries

Sponsor:

University of Nevada, Las Vegas

Code:

NCT06828159

Conditions

Gut -Microbiota

Inflammation Biomarkers

Pain Assessment

Joint Pain

Eligibility Criteria

Sex: All

Age: 40 - 70+

Healthy Volunteers: Not accepted

Interventions

Wild blueberry

Placebo

Study Details

Brief summary:

The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.

Conditions

Gut -Microbiota

Inflammation Biomarkers

Pain Assessment

Joint Pain

Study ID

NCT06828159

Start date

Sep 1, 2025

Status verified date

Sep, 2025

Completion date

Mar, 2028

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults with documented multi-joint/knee arthritis

Exclusion Criteria:

  • inability to give informed consent
  • pregnancy or lactation
  • planned knee replacement surgery
  • allergy or contraindication to berries
  • recent trauma of the knee responsible of the symptomatic knee
  • intra-articular injection in the target knee/hip in the last 3 months
  • oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline
  • use of berry extracts in the last 3 months
  • special diets
  • cancer treatment
  • bone diseases

Study Design

Enrollment

50 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Wild blueberries

25g freeze-dried wild blueberries daily for 12 weeks

placebo comparator: Placebo

Placebo powder free from polyphenols matched for calories

Interventions

Wild blueberry

Freeze-dried wild blueberry powder 25g/day

Placebo

Placebo powder matched for calories and no polyphenols

Primary outcome measure

  • Serum biomarkers of joint function [ Time Frame: 12 weeks ]

Central Contacts and Locations

Central contacts

Arpita Basu

702-895-4576arpita.basu@unlv.edu

Locations

OMRF

Recruiting

Oklahoma City, Oklahoma, United States, 73104

Contacts

Judy Goodman

405- 271-3007judy-goodman@omrf.org

More Information

Sponsor

University of Nevada, Las Vegas

Last update posted

Nov 5, 2025

Last verified

Sep, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Nevada, Las Vegas on 2025-11-05.