Recruiting

tDCS

Sponsor:

Yale University

Code:

NCT06830174

Conditions

Laryngeal Dystonia

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

Starstim system

Study Details

Brief summary:

This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).

Conditions

Laryngeal Dystonia

Study ID

NCT06830174

Start date

Apr 14, 2025

Status verified date

Feb, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Participants must be clinically evaluated for the diagnosis of LD or have the proof of LD diagnosis. (Not applicable for control participants)
  • No other known or history of speech, voice disorder other than LD.
  • Provision of signed and dated informed consent form.
  • Stated willingness to comply with all study procedures and availability for the duration of the study
  • Must not be pregnant.

Exclusion Criteria:

  • All individuals who do not meet the above mentioned criteria are excluded from the study.
  • Subjects with a history of epilepsy or depression or is claustrophobic.

Study Design

Enrollment

10 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Laryngeal Dystonia (LD) tDCS

Adductor, Abductor and Mixed type LD with clinical evaluation of LD or with proof of LD diagnosis

Interventions

Starstim system

Transcranial direct current stimulation (tDCS)

Primary outcome measure

  • Change in Cepstral peak prominence (CPP) [ Time Frame: daily on Day 1-Day 5 ]
  • Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) [ Time Frame: daily on Day 1-Day 5 ]

Central Contacts and Locations

Central contacts

Nabin Koirala, PhD

203 7852527nabin.koirala@yale.edu

Locations

Yale University

Recruiting

New Haven, Connecticut, United States, 06511

Contacts

Nabin Koirala, PhD

203-785-2527nabin.koirala@yale.edu

More Information

Sponsor

Yale University

Last update posted

Feb 9, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Yale University on 2026-02-09.