Recruiting

Phase 2

MZE829A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

Sponsor:

Maze Therapeutics

Code:

NCT06830629

Conditions

Proteinuric Kidney Disease

Eligibility Criteria

Sex: All

Age: 18 - 68

Healthy Volunteers: Not accepted

Interventions

MZE829

Study Details

Brief summary:

The purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease.

Conditions

Proteinuric Kidney Disease

Study ID

NCT06830629

Start date

Feb 5, 2025

Status verified date

Jul, 2026

Completion date

Sep, 2026

Anticipated

Primary completion date

Sep, 2026

Anticipated

Eligibility Criteria

Sex: All

Age: 18 - 68

Healthy Volunteers: Not accepted

Key Inclusion Criteria:

APOL1 high risk genotype of G1/G1, G2/G2, or G1/G2
Chronic kidney disease with persistent albuminuria

Key Exclusion Criteria:

Organ or bone marrow transplantation
History of active cancer within past 2 years, except for treated non-melanoma skin cancer, stage 0 cervical cancer, or stage 1 prostate cancer
Conditions that may alter drug absorption, e.g., history of bariatric surgery
Type I diabetes
Pregnant or currently nursing

Other inclusion/exclusion criteria defined in protocol apply.

Study Design

Enrollment

74 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: MZE829

Cohort 1: Chronic kidney disease with concurrent diabetes

Cohort 2: Chronic kidney disease without concurrent diabetes

Interventions

MZE829

Capsules for oral administration

Primary outcome measure

Safety and tolerability as assessed by incidence of adverse events (AEs) [ Time Frame: Baseline to Week 12 ]

Central Contacts and Locations

Central contacts

Maze Therapeutics

650-850-5075 APOL1info@mazetx.com

Locations

Research Site

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Decatur, Alabama, United States, 35601

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Huntsville, Alabama, United States, 35805

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Montgomery, Alabama, United States, 36106

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Montgomery, Alabama, United States, 36117

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Bloomfield, Connecticut, United States, 06112

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Washington D.C., District of Columbia, United States, 20060

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Atlantis, Florida, United States, 33462

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Brandon, Florida, United States, 33511

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Hollywood, Florida, United States, 33024

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Melbourne, Florida, United States, 32901

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Orlando, Florida, United States, 32822

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Atlanta, Georgia, United States, 30309

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College Park, Georgia, United States, 30349

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Cordele, Georgia, United States, 31015

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Macon, Georgia, United States, 31210

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Riverdale, Georgia, United States, 30274

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Riverdale, Georgia, United States, 30296

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Savannah, Georgia, United States, 31406

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Snellville, Georgia, United States, 30078

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Chicago, Illinois, United States, 60616

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Chicago, Illinois, United States, 60643

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Evanston, Illinois, United States, 60201

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Kansas City, Kansas, United States, 66112

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Bowling Green, Kentucky, United States, 42101

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Louisville, Kentucky, United States, 40205

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Arnold, Maryland, United States, 21012

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Lutherville, Maryland, United States, 21093

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Oxon Hill, Maryland, United States, 20745

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Dearborn, Michigan, United States, 48126

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Flint, Michigan, United States, 48503

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Pontiac, Michigan, United States, 48341

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Saint Joseph, Michigan, United States, 49085

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Minneapolis, Minnesota, United States, 55404

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Tupelo, Mississippi, United States, 38801

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City of Saint Peters, Missouri, United States, 63376

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St Louis, Missouri, United States, 63103

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Las Vegas, Nevada, United States, 89107

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Jersey City, New Jersey, United States, 07305

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Buffalo, New York, United States, 14203

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Laurelton, New York, United States, 11413

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Maspeth, New York, United States, 11378

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Newburgh, New York, United States, 12550

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Durham, North Carolina, United States, 27708

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Fayetteville, North Carolina, United States, 28304

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Greensboro, North Carolina, United States, 27405

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Shelby, North Carolina, United States, 28150

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Cleveland, Ohio, United States, 44106

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Cleveland, Ohio, United States, 44195

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Columbus, Ohio, United States, 43215

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Ardmore, Oklahoma, United States, 73401

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Philadelphia, Pennsylvania, United States, 19104

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Philadelphia, Pennsylvania, United States, 19107

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Upland, Pennsylvania, United States, 19013

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Columbia, South Carolina, United States, 29203

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Spartanburg, South Carolina, United States, 29302

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Spartanburg, South Carolina, United States, 29306

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Chattanooga, Tennessee, United States, 37404

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Dallas, Texas, United States, 75230

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Dallas, Texas, United States, 75246

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Greenville, Texas, United States, 75402

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Houston, Texas, United States, 77030

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Houston, Texas, United States, 77054

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Houston, Texas, United States, 77099

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McKinney, Texas, United States, 75069

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San Antonio, Texas, United States, 78251

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Shenandoah, Texas, United States, 77384

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Sherman, Texas, United States, 75092

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Norfolk, Virginia, United States, 23504

More Information

Sponsor

Maze Therapeutics

Last update posted

Jul 27, 2026

Last verified

Jul, 2026

Keywords

APOL1-mediated kidney disease (AMKD)
APOL1 kidney disease (AKD)

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Maze Therapeutics on 2026-07-27.