Recruiting

Move More

Sponsor:

University of Arizona

Code:

NCT06830993

Conditions

Hemodialysis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

"Move More" Personalized Exercise Program

Intradialytic Exercise Program

Study Details

Brief summary:

The goal of this clinical trial is to compare the efficacy of a standard intradialytic exercise program (control group) to an individualized, patient-centered, "Move-More" physical activity intervention (intervention group) in hemodialysis (HD) patients.

Exercise programs often fail to yield robust benefits for many HD patients, in part because the type and volume of exercise prescribed is inappropriate for a variety of reasons, and the benefits from these studies are often disappointing, as they are characterized by poor adherence, high dropout rates, and modest effects on physical function, body composition, cardiovascular disease risk, and other outcomes related to quality of life (QOL). To address this, the investigators have designed a novel physical activity intervention "Move More" that is designed to overcome many of the barriers to increasing physical activity in this population. This study aims to compare the efficacy of a standard intradialytic exercise program (control group) to an individualized, patient-centered, "Move-More" physical activity intervention (intervention group) in HD patients. The investigators primary hypothesis is that patients randomized to the Move More intervention will increase their physical activity levels more than those in the intradialytic exercise group.

The main question it aims to answer is:

• Does "Move More" increase the physical activity levels (minutes) measured through weekly minutes of physical activity and the LoPAQ questionnaire more than those in the standard intradialytic exercise program?

For secondary outcomes this study aims to answer the following:

  • Does "Move More" improve the physical function of hemodialysis patients assessed by the short physical performance battery (SPBB) more than those in the standard intradialytic exercise program?
  • Does "Move More" decrease fatigue assess by the SONG-HD survey more than those in the standard intradialytic exercise program?
  • Does "Move More" decrease symptoms of depression assessed by PROMIS Depression Short Form 8a more than those in the standard intradialytic exercise program?
  • Does "Move More" increase the amount of exercise measured through a point system more than those in the standard intradialytic exercise program?
  • Does "Move More" improve blood pressure (BP) more than those in the standard intradialytic exercise program?

Conditions

Hemodialysis

Study ID

NCT06830993

Start date

Jul 1, 2025

Status verified date

Aug, 2025

Completion date

Oct, 2026

Anticipated

Primary completion date

Aug, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • ≥ 18 years old (no upper age limit);
  • Chronic hemodialysis for ≥ 3 months;
  • No planned or expected change in dialysis modality, elective surgery, or relocation during the study period (24 weeks);
  • Able to communicate in English or Spanish and provide written informed consent;
  • Assessed to be safe and able to exercise by the Hemodialysis unit nephrologist

Exclusion Criteria:

  • Physical Activity: patients undergoing >150 minutes/week of prescribed PA at baseline will be excluded from the study.
  • Physician Clearance: Patients who do not receive physician clearance to participate in the study will be excluded from the study.

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Move More Personalized Exercise Program

Personalized physical activity program aimed to increase the physical activity levels determined through a point system. Points are derived from metabolic equivalent (MET) scores and can be accumulated by performing any activity (e.g., "lifestyle" activities, aerobic, and/or resistance exercises) the participants complete. Weekly challenges/goals will be set to encourage participants to increase their physical activity levels. Participants will have the autonomy to decide about their weekly challenges or goals.

active comparator: Intradialytic Exercise Program

Participation in an Intradialytic cycling (exercise during dialysis) physical activity prescription and resistance ("strength training") exercise for 6 months.

Interventions

"Move More" Personalized Exercise Program

"Move More" - a personalized exercise program involving both in center and out-of-center exercise. Our novel intervention provides patient's the autonomy to choose the types of physical activity and exercise that they are willing and able to participate in. In brief, it involves working one-on-one with patients to develop an activity prescription that aims to get participants to "move more", by any means necessary.

Intradialytic Exercise Program

Those in the intradialytic exercise group will undergo a variety of exercises including intradialytic cycling and resistance ("strength training").

Primary outcome measure

  • Change in Physical Activity [ Time Frame: baseline, 3 months, 6 months ]

Central Contacts and Locations

Central contacts

Kenneth R Wilud, PhD

520.621.3096kwilund@arizona.edu

Geovana R Martin Alemany, PhD

520.870.7078martinalemany@arizona.edu

Locations

DCI Desert Dialysis

Recruiting

Tucson, Arizona, United States, 85719

Contacts

Patty Blankenship, RN

(520) 327-0007patty.blankenship@dciinc.org

More Information

Sponsor

University of Arizona

Last update posted

Aug 24, 2025

Last verified

Aug, 2025

Keywords

  • hemodialysis
  • physical activity
  • fatigue
  • physical function
  • exercise
  • patient reported outcome

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Arizona on 2025-08-24.