Recruiting

Observational StudyThe ROAR Study: Reactive Oxygen Species and Reproduction

Sponsor:

UCLA

Code:

NCT06831019

Conditions

Ovarian Aging

IVF Outcome

Oxidative Stress

Eligibility Criteria

Sex: All

Age: 18 - 43

Healthy Volunteers: Accepted

Interventions

Oxidative stress markers

Study Details

Brief summary:

This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.

Conditions

Ovarian Aging

IVF Outcome

Oxidative Stress

Study ID

NCT06831019

Start date

Jul 7, 2025

Status verified date

Feb, 2026

Completion date

Mar 1, 2027

Anticipated

Primary completion date

Mar 1, 2027

Anticipated

Eligibility Criteria

Sex: All

Age: 18 - 43

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Female age 18-43 years
2. Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
3. Male partners 18 years of age or older.
4. Must be a registered patient at UCSF Center for Reproductive Health
5. Patient and partner must both be physically present on the day of retreival

Exclusion Criteria:

1. Female partner age 44 or older
2. Planning fresh transfer (hybrid PGS cycle)
3. Cleavage stage biopsy
4. Planning to use frozen sperm

Study Design

Enrollment

1100 participants

Anticipated

Interventions and Outcome Measures

Arms

Couples undergoing IVF

Heterosexual couples undergoing IVF

Interventions

Oxidative stress markers

We will measure markers of oxidative stress in the follicular fluid, semen, and blood and correlate this with IVF and reproductive outcomes

Primary outcome measure

Implantation rate [ Time Frame: From enrollment to transfer of all embryos - can be anywhere from 8 weeks to 1 year (or sometimes longer if pregnancy is achieved) ]

Central Contacts and Locations

Central contacts

Elena Hoskin, BS

(415) 885-3598 elena.hoskin@ucsf.edu

Locations

University of California, San Francisco

Recruiting

San Francisco, California, United States, 94158

More Information

Sponsor

University of California, San Francisco

Last update posted

Feb 17, 2026

Last verified

Feb, 2026

Keywords

oxidative stress
ovarian aging

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-02-17.