Recruiting

Observational Study

Sponsor:

University of Iowa

Code:

NCT06831110

Conditions

Aquagenic Wrinkling of Palms

Carrier State

Eligibility Criteria

Sex: All

Age: 18 - 24

Healthy Volunteers: Accepted

Interventions

Aquagenic Wrinkling

Study Details

Brief summary:

The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status.

Participants will complete one visit where they will undergo an aquagenic wrinkling procedure to see how their hands respond.

Conditions

Aquagenic Wrinkling of Palms

Carrier State

Study ID

NCT06831110

Start date

Mar 6, 2025

Status verified date

Jun, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 24

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Interested in participating in other CF Carrier-related research studies.

Exclusion Criteria:

  • CF patient status
  • Unable to speak English
  • Unable to provide written informed consent
  • Prisoner status
  • An open wound on either hand
  • A tattoo on either hand
  • Missing any portion of either hand
  • Diagnosis of Diabetes
  • Diagnosis of Hyperhidrosis
  • Diagnosis of Raynaud's Disease
  • Diagnosis of Atopic Dermatitis
  • Regularly taking ACE inhibitors or angiotensin receptor blockers

Study Design

Enrollment

2000 participants

Anticipated

Interventions and Outcome Measures

Arms

Potential Cystic Fibrosis Carriers

Participants that are identified as potential cystic fibrosis carriers based on aquagenic wrinkling results.

Potential Controls

Participants that are identified as potential controls based on aquagenic wrinkling results.

Interventions

Aquagenic Wrinkling

Participants will be asked to remove all jewelry from the hand(s) and wrist(s) that will be undergoing the aquagenic wrinkling procedures. Photographs will be taken of the palmar surface of the hand(s). The participant will submerge the hand(s) undergoing testing in a water bath for one minute. After one minute, they will remove their hand(s), dry them gently with a towel, and photographs will be taken of the palmar surface of the hand(s). The participant will re-submerge their hand(s) in the appropriate conditions for another minute and the process will be repeated 20 times for 20 total minutes submerged in the water.

Primary outcome measure

  • Human Observation of Wrinkling [ Time Frame: Up to 20 minutes ]
  • Machine-Learning Observation of Wrinkling [ Time Frame: Up to 20 minutes ]

Central Contacts and Locations

Central contacts

Philip M Polgreen, MD

319-384-6194philip-polgreen@uiowa.edu

Shelby L Francis, PhD

319-678-8037shelby-francis@uiowa.edu

Locations

University of Iowa

Recruiting

Iowa City, Iowa, United States, 52242

Contacts

Shelby Francis, PhD

319-678-8037shelby-francis@uiowa.edu

More Information

Sponsor

University of Iowa

Last update posted

Jun 4, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Iowa on 2026-06-04.