Recruiting

Pulmonary Rehabilitation

Sponsor:

Mayo Clinic

Code:

NCT06847061

Conditions

Chronic Obstructive Pulmonary Disease (COPD

Eligibility Criteria

Sex: All

Age: 40+

Healthy Volunteers: Not accepted

Interventions

Pulmonary rehabilitation program

Study Details

Brief summary:

The purpose of this study is to test the uptake, effectiveness, and patient-caregiver-provider experience of a crucial treatment not provided in rural areas: pulmonary rehabilitation.

Conditions

Chronic Obstructive Pulmonary Disease (COPD

Study ID

NCT06847061

Start date

Apr 1, 2025

Status verified date

May, 2026

Completion date

Aug 31, 2029

Anticipated

Primary completion date

Aug 31, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40+

Healthy Volunteers: Not accepted

Inclusion Criteria

  • 40 years of age or older
  • Physician-diagnosed COPD
  • Living in a rural area defined by Rural-Urban Commuting Area Codes 4-10
  • mMRC score>=1
  • English Speaking

Exclusion Criteria

  • Inability to walk (orthopedic/neurologic/cardiac limitation causing immobility)
  • Cognitive impairment or inability to understand and follow instructions.
  • Patients with no COPD symptom burden, no breathlessness (mMRC score 0), as based on our previous studies they usually perceive no benefit from PR and do not have compliance with PR.
  • Traditional center-based PR was completed within 3 months of initial study recruitment.
  • Transition to hospice or end-of-life care at the time of screening.
  • Acute exacerbation at the time of screening.

Study Design

Enrollment

306 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Treatment Group

Subjects randomized to the treatment arm will begin the home-based pulmonary rehabilitation intervention immediately.

experimental: Waitlist Control

Subjects randomized to the waitlist control (usual care) arm will be offered the home-based pulmonary rehabilitation intervention after completing the 12-week control period.

Interventions

Pulmonary rehabilitation program

Participants are expected to engage in the home-based pulmonary rehabilitation routine at least 24 minutes a day, five to six days a week for the entire 12-week study period.

The pulmonary rehabilitation routine begins with slow upper body and timed breathing exercises, followed by two slow balance walks for 6 minutes each. The total exercise time again is 24 minutes, followed by a 4-minute mindful breathing meditation/cool down

Primary outcome measure

  • Change Chronic Respiratory Questionnaire Physical and Emotional (CRQ-SAS) summary scores [ Time Frame: Baseline, 3 months ]

Central Contacts and Locations

Central contacts

Johanna Hoult, M.A.

507-293-1989Hoult.Johanna@mayo.edu

Locations

Mayo Clinic in Arizona

Recruiting

Scottsdale, Arizona, United States, 85259

Principal Investigator:

Roberto P Benzo

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Principal Investigator:

Teng Moua, M.D.

More Information

Sponsor

Mayo Clinic

Last update posted

May 7, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-05-07.